ULK
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ULK Verwandte Produkte (15)
Verwandte Produkte (15)
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GW406108X
0 ImagesSynonyms: GW108XGW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
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13-Oxyingenol-13-dodecanoate
0 ImagesArt. -Nr.: HY-N0867CAS. Nr.: 54706-70-613-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM.13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis.
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UE01
0 ImagesArt. -Nr.: HY-184501CAS. Nr.: 486440-74-8UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2. UE01 activates hULK1 with an EC50 of 695.30 nM and a KD of 114.3 nM for ULK1; it inhibits hERK1 with an IC50 of 179.90 nM and a KD of 114 nM for ERK1; it shows weak binding to ERK2 with a KD of 2.8 mM. UE01 induces the conformational transition of ULK1 from an inactive to an active state, enhances the phosphorylation of ULK1 Ser317 and mAtg13 Ser355, and reduces the phosphorylation of ULK1 Ser757. UE01 competitively occupies the ATP-binding pocket of ERK1, inhibits ERK1 kinase activity, and reduces the activity of the ERK1/2 signaling pathway. UE01 induces complete autophagy flux and apoptosis, upregulates Atg5, Atg7, LC3-II/LC3-I, Bax, cytochrome C (Cyt c), Cleaved-Caspase 3, Cleaved-PARP1 and E-cadherin, downregulates p62, Bcl-2, MMP-2 and MMP-9, reduces the phosphorylation of Exo70 Ser250, and promotes the proteasome-dependent degradation of Cav-1, thereby inhibiting EMT-related phenotypes and extracellular matrix degradation. UE01 can be used in studies related to triple-negative breast cancer.
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ULK1-IN-4
0 ImagesArt. -Nr.: HY-181668ULK1-IN-4 (compound 12i) is a ULK1 inhibitor with an IC50 of 4.7 μM against human ULK1, and it exhibits selectivity for Aurora A/Aurora B kinases. ULK1-IN-4 forms a covalent bond with the thiol group of the Cys182 residue of ULK1, thereby inhibiting the kinase activity of ULK1. ULK1-IN-4 inhibits the growth of colorectal cancer cells and exerts tumor-suppressive activity in a mouse model of colorectal cancer.
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(Z/E)-GW406108X
0 ImagesArt. -Nr.: HY-115570ACAS. Nr.: 265098-01-9Synonyms: (Z/E)-GW108X(Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
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MRT67307 dihydrochloride
0 ImagesArt. -Nr.: HY-13018BCAS. Nr.: 1781882-89-0
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ULK1 Recombinant Human Active Protein Kinase
0 ImagesArt. -Nr.: HY-E70875ULK1 (unc-51 like autophagy activating kinase 1), one of the core human autophagy-related genes, encodes a serine-threonine kinase and the mammalian ortholog of the yeast ATG1 gene. ULK1 Recombinant Human Active Protein Kinase is a recombinant ULK1 protein that can be used to study ULK1-related functions.
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LYN-1604 (Standard)
0 ImagesArt. -Nr.: HY-101923RCAS. Nr.: 2088939-99-3
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MRT68921 dihydrochloride (Standard)
0 ImagesMRT68921 (dihydrochloride) (Standard) is the analytical standard of MRT68921 (dihydrochloride) (HY-100006A). This product is intended for research and analytical applications. MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer.
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LYN-1604 dihydrochloride (Standard)
0 ImagesArt. -Nr.: HY-101923BRCAS. Nr.: 2310109-38-5LYN-1604 dihydrochloride (Standard) is the analytical standard of LYN-1604 dihydrochloride (HY-101923B). This product is intended for research and analytical applications. LYN-1604 dihydrochloride is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).
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