2. Signaling Pathways
  3. Autophagy
  4. ULK
  5. ULK Isoform
  6. ULK Inhibitor

ULK Inhibitor

ULK Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-115570
    GW406108X
    		Inhibitor 98.0%
    GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK.
  • HY-RS15451
    ULK1 Human Pre-designed siRNA Set A
    		Inhibitor

    ULK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS15452
    Ulk1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ulk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-181668
    ULK1-IN-4
    		Inhibitor
    ULK1-IN-4 (compound 12i) is a ULK1 inhibitor with an IC50 of 4.7 μM against human ULK1, and it exhibits selectivity for Aurora A/Aurora B kinases. ULK1-IN-4 forms a covalent bond with the thiol group of the Cys182 residue of ULK1, thereby inhibiting the kinase activity of ULK1. ULK1-IN-4 inhibits the growth of colorectal cancer cells and exerts tumor-suppressive activity in a mouse model of colorectal cancer.
  • HY-RS15454
    ULK2 Human Pre-designed siRNA Set A
    		Inhibitor

    ULK2 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-115570A
    (Z/E)-GW406108X
    		Inhibitor
    (Z/E)-GW406108X is a mixture of different configurations of GW406108X (HY-115570). GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM.
  • HY-13018B
    MRT67307 dihydrochloride
    		Inhibitor
    MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.
  • HY-RS15455
    Ulk2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ulk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-100006AR
    MRT68921 dihydrochloride (Standard)
    		Inhibitor
    MRT68921 (dihydrochloride) (Standard) is the analytical standard of MRT68921 (dihydrochloride) (HY-100006A). This product is intended for research and analytical applications. MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer.