Art. -Nr.: HY-Y0921

(±)-1,2-Propanediol

(Synonyms: 1,2-(RS)-Propanediol; 1,2-Propylene glycol; Propylene glycol)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish.

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Reinheit: 99.97%
CAS. Nr.: 57-55-6
Formel: C₃H₈O₂
Molecular Weight:76.09

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(±)-1,2-Propanediol Chemical Structure

CAS. Nr.: 57-55-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

(±)-1,2-Propanediol (Propylene glycol) is a frequently used excipient in many drug formulations to increase the solubility and/or stability of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Studies in animal models show that (±)-1,2-Propanediol is rapidly absorbed (within ~1 h) after oral or intravenous administration. Upon absorption, (±)-1,2-Propanediol is uniformly distributed in total body water without a significant distribution to specific tissues. (±)-1,2-Propanediol is primarily metabolized in the liver by alcohol dehydrogenase (ADH; EC 1.1.1.1) into lactaldehyde, which is then metabolized by aldehyde dehydrogenase (ALDH; EC 1.2.1.3) into lactic acid. It is further metabolized by lactate dehydrogenase (LDH; EC 1.1.1.27) into pyruvate that is eventually metabolized into CO₂ and H₂O within the citric acid cycle^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 57-55-6
Appearance Liquid (Density: 1.036 g/cm³)
Molecular Weight 76.09
Formel C₃H₈O₂
Color Colorless to light yellow
SMILES

CC(O)CO
Synonyms

1,2-(RS)-Propanediol; 1,2-Propylene glycol; Propylene glycol
Initial Source

Clostridium strain AK1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Journal Impact Factor

J Nanobiotechnology

Unveiling new therapeutic targets for esophageal cancer treatment through single-cell transcriptomics: pH-responsive nanobubbles enhance the efficacy of 125I radiotherapy. [Abstract]

2025 Jul 15;23(1):515. PMID: 40665303
Commun Biol

Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia. [Abstract]

2024 Oct 4;7(1):1257. PMID: 39362994
iScience

Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats. [Abstract]

2023 Nov 3;26(12):108392. PMID: 38025767

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (1314.23 mM; Need ultrasonic)

DMSO : 100 mg/mL (1314.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

13.1423 mL

65.7117 mL

131.4233 mL

5 mM

2.6285 mL

13.1423 mL

26.2847 mL

10 mM

1.3142 mL

6.5712 mL

13.1423 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87. [Content Brief]

[2]. Massarsky A, et al. Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). Neurotoxicology. 2018 Mar;65:111-124. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	13.1423 mL	65.7117 mL	131.4233 mL	328.5583 mL
	5 mM	2.6285 mL	13.1423 mL	26.2847 mL	65.7117 mL
	10 mM	1.3142 mL	6.5712 mL	13.1423 mL	32.8558 mL
	15 mM	0.8762 mL	4.3808 mL	8.7616 mL	21.9039 mL
	20 mM	0.6571 mL	3.2856 mL	6.5712 mL	16.4279 mL
	25 mM	0.5257 mL	2.6285 mL	5.2569 mL	13.1423 mL
	30 mM	0.4381 mL	2.1904 mL	4.3808 mL	10.9519 mL
	40 mM	0.3286 mL	1.6428 mL	3.2856 mL	8.2140 mL
	50 mM	0.2628 mL	1.3142 mL	2.6285 mL	6.5712 mL
	60 mM	0.2190 mL	1.0952 mL	2.1904 mL	5.4760 mL
	80 mM	0.1643 mL	0.8214 mL	1.6428 mL	4.1070 mL
	100 mM	0.1314 mL	0.6571 mL	1.3142 mL	3.2856 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

(±)-1,2-Propanediol

3 Cited Publications

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(±)-1,2-Propanediol

Publications Citing Use of MedChemExpress (MCE) (±)-1,2-Propanediol

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

(±)-1,2-Propanediol Related Classifications

HY-Y0921 Related Classifications