ALK5-IN-29
ALK5-IN-29 is an selective activin receptor-like kinase (ALK) inhibitor. ALK5-IN-29 can inhibit the activity of ALK5 with an IC50 value of ≤10 nM. ALK5-IN-29 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2785430-85-3
- Formel: C24H25FN8
- Molecular Weight:444.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IC50: ≤10 nM (ALK5/2); ≤100 nM (RD-SMAD receptor)[1]
ALK5-IN-29 (EX-06) has kinase inhibition of ALK5 with an IC50 value of ≤10 nM[1].
ALK5-IN-29 has kinase selectivity of ALK2/ALK5 with an IC50 value of ≤10 nM[1].
ALK5-IN-29 shows TGFB-RI inhibition (RD-SMAD receptor activity) with an IC50 value of ≤100 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2785430-85-3
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Molecular Weight 444.51
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Formel C24H25FN8
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SMILES
CC1=CC=CC2=C(NC3=NC(NC4=CC(CN5CCNCC5)=CC(F)=C4)=NC=C3)C=NN=C12
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ALK5-IN-29 Related Classifications
HY-151277 Related Classifications
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