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Art. -Nr.: HY-N10062

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Amakusamine

Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

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CAS. Nr.: 2923661-84-9
Formel: C₉H₅Br₂NO₂
Molecular Weight:318.95

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Amakusamine Chemical Structure

CAS. Nr.: 2923661-84-9

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	10.5 μM Compound: 1; natural	Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay	[PMID: 34612636]
RAW264.7	IC₅₀	9.4 μM Compound: 1; Synthetic	Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay Inhibition of RANKL-induced osteoclastogenesis in mouse RAW264.7 cells assessed as reduction in number of TRAP-positive multinuclear cells measured after 4 days by TRAP staining based assay	[PMID: 34612636]

Chemical Information

CAS. Nr. 2923661-84-9
Molecular Weight 318.95
Formel C₉H₅Br₂NO₂
SMILES

BrC1=C2OCOC2=C(C3=C1C=CN3)Br
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Maeyama Y, et al. Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts. J Nat Prod. 2021 Oct 22;84(10):2738-2743. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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