Aplodan
Based on 1 Customer Validation
Aplodan (Creatinol O-phosphate) is an antiischemic and antiarrhythmic agent. Aplodan has a protective action on cell membrane. Aplodan has the potential for the research of ischemic heart or acute myocardial infarction .
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.20%
- CAS. Nr.: 6903-79-3
- Formel: C4H12N3O4P
- Molecular Weight:197.13
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Aplodan (1-10 mM; 30 min) can decrease Phosphocreatine and ATP signals in isolated heart of Xenopus Africanus and affect cardiometabolic metabolism in the 31P NMR spectroscopy study[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 6903-79-3
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Appearance Solid
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Molecular Weight 197.13
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Formel C4H12N3O4P
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Color White to off-white
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SMILES
N=C(N)N(C)CCOP(O)(O)=O
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Synonyms
Creatinol O-phosphate; Creatinol phosphate; Creatinolfosfate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
H2O : 62.5 mg/mL (317.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Olsen JI, et al. A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain. Pharmacol Res. 1993 Sep;28(2):135-51. [Content Brief]
[2]. Botti G, et al. Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects. Arzneimittelforschung. 1979;29(9a):1491-1494. [Content Brief]
[3]. Di Maio F, et al. Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial. Arzneimittelforschung. 1979;29(9a):1488-1490. [Content Brief]
[4]. Knippel M, et al. Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction. Arzneimittelforschung. 1979;29(9a):1480-2. [Content Brief]
[5]. Godfraind T, et al. An analysis of the reduction by creatinol O-phosphate of the myocardial lesions evoked by isoprenaline in the rat. Arzneimittelforschung. 1979;29(9a):1457-64. [Content Brief]
[6]. Marchetti G, et al. Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs. Arzneimittelforschung. 1978;28(10):1708-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0728 mL | 25.3640 mL | 50.7279 mL | 126.8199 mL |
| 5 mM | 1.0146 mL | 5.0728 mL | 10.1456 mL | 25.3640 mL | |
| 10 mM | 0.5073 mL | 2.5364 mL | 5.0728 mL | 12.6820 mL | |
| 15 mM | 0.3382 mL | 1.6909 mL | 3.3819 mL | 8.4547 mL | |
| 20 mM | 0.2536 mL | 1.2682 mL | 2.5364 mL | 6.3410 mL | |
| 25 mM | 0.2029 mL | 1.0146 mL | 2.0291 mL | 5.0728 mL | |
| 30 mM | 0.1691 mL | 0.8455 mL | 1.6909 mL | 4.2273 mL | |
| 40 mM | 0.1268 mL | 0.6341 mL | 1.2682 mL | 3.1705 mL | |
| 50 mM | 0.1015 mL | 0.5073 mL | 1.0146 mL | 2.5364 mL | |
| 60 mM | 0.0845 mL | 0.4227 mL | 0.8455 mL | 2.1137 mL | |
| 80 mM | 0.0634 mL | 0.3170 mL | 0.6341 mL | 1.5852 mL | |
| 100 mM | 0.0507 mL | 0.2536 mL | 0.5073 mL | 1.2682 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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