ARC 239 (Standard)
ARC 239 Standard is the analytical standard of ARC 239 (HY-12709). This product is intended for research and analytical applications. ARC 239 is a selective α2B/C-adrenoceptor antagonist, with pKi values of 5.45, 7.06, and 6.95 for α2A, α2B, and α2C receptors, respectively. ARC 239 selectively antagonizes α2B-AR, blocking norepinephrine signaling and downstream RhoA/ROCK activation and Claudin-5 disruption, without altering plasma norepinephrine levels in the distal tail artery of mice, and does not inhibit α2-adrenoceptor-mediated vasoconstriction. ARC 239 also binds with high affinity to 5-HT1A receptors, with a Ki of 63.1 nM, thereby interfering with subtype-selective α2-adrenoceptor assays. ARC 239 can be used for research on cardiovascular diseases and inflammatory skin diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 67339-62-2
- Formel: C24H29N3O3
- Molecular Weight:407.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 67339-62-2
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Molecular Weight 407.51
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Formel C24H29N3O3
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SMILES
O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Gavin KT, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):406-11. [Content Brief]
[2]. Meana JJ, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312(3):385-8. [Content Brief]
[3]. Yu Y, et al. A stress-responsive neurovascular axis shapes skin immune accessibility. iScience. 2026 Mar 20;29(3):115122. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ARC 239 (Standard) Related Classifications
HY-12709R Related Classifications
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