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Art. -Nr.: HY-188045

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AS3513678

AS3513678 is a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptor (m-nAChR). AS3513678 promotes acetylcholine (ACh) signaling via m-nAChR, shifts the ACh concentration-response curve to the left, and does not activate the receptor in the absence of ACh. AS3513678 can be used for research on myasthenia gravis and congenital myasthenic syndrome.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₆H₁₇F₄N₃O₄S₂
Molecular Weight:575.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AS3513678 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

AS3513678 (1-10 μM) acts as a positive allosteric modulator of skeletal muscle-type nicotinic acetylcholine receptors in differentiated Hu5/KD3 human myotubes, reducing the EC₅₀ of ACh by 7.8-fold at a concentration of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 575.55
Formel C₂₆H₁₇F₄N₃O₄S₂
SMILES

FC1=CC(C2=C(C(F)(F)F)N=C(NC(C(N3C)=C(O)C4=C(C=CC=C4)S3(=O)=O)=O)S2)=CC=C1C5=CC=CC=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Saito A, et al. Discovery and pharmacological characterization of novel positive allosteric modulators acting on skeletal muscle-type nicotinic acetylcholine receptors. Biochemical and biophysical research communications. 2023 Aug 06;668:27-34.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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