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Atesidorsen

(Synonyms: COR-004; ATL1103; ISIS 227452)

Atesidorsen (COR-004, ATL1103) is an antisense oligonucleotide targeting the growth hormone receptor (GHR). Atesidorsen binds to GHR mRNA, inhibits human GHR translation, and reduces GHR synthesis through RNase H degradation. Atesidorsen reduces hepatic GHR mRNA and serum IGF-I. Atesidorsen can be used in research related to acromegaly.

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  • Atesidorsen Chemical Structure
    Atesidorsen Chemical Structure
CAS. Nr.: 872063-57-5
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  • Atesidorsen Chemical Structure
    Atesidorsen Chemical Structure DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rG-G-m5C-A-T-T-m5C-T-T-T-m5C-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC)
    1/16
  • DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rG-G-m5C-A-T-T-m5C-T-T-T-m5C-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC)