Aβ aggregation-IN-4
Aβ aggregation-IN-4 can alleviate the neurotoxicity of amyloid-β protein (Aβ) and significantly reduce the level of oligomeric complexes of Aβ (Aβ-OCs). Aβ aggregation-IN-4 does not decrease the level of amyloid-β protein (Aβ). Aβ aggregation-IN-4 attenuates Aβ oligomerization and prevents oligomer-induced death of primary cortical neurons. Aβ aggregation-IN-4 can be used for the study of Alzheimer’s disease (AD).
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- CAS. Nr.: 603113-07-1
- Formel: C21H23N5O3
- Molecular Weight:393.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Beschreibung
In Vitro
Aβ aggregation-IN-4 (0-2 μM, 24-48 hours) can protect MC65 cells and reduce the level of intracellular Aβ oligomers in MC65 cells in a dose-dependent manner (EC50=0.15 μM)[1].
Aβ aggregation-IN-4 (0-14 hours) is a cell-permeable compound. [14C]Amyloid-β-IN-4 can reach a saturated concentration in MC65 cells within 2 hours and can enter the cells rapidly[1].
The binding affinities (Kd) of Aβ aggregation-IN-4 to Aβ40 and Aβ42 are 5.05 nM and 269 nM, respectively[1].
Aβ aggregation-IN-4 (10 μM, 24 hours) can significantly reduce the density of Aβ40 and Aβ42 oligomers[1].
Aβ aggregation-IN-4 (50 nM, 48 hours) can block the neurotoxicity of extracellular Aβ oligomers in primary neuron cultures of the neonatal mouse cortex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cultures of cortical neurons from newborn mice
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Concentration:50 nM
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Incubation Time:48 h
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Result:Blocked the neurotoxicity of extracellular Aβ oligomers in primary cultures of cortical neurons from newborn mice.
Chemical Information
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CAS. Nr. 603113-07-1
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Molecular Weight 393.44
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Formel C21H23N5O3
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SMILES
[H][C@]12C[C@H](CCC1=CC3=C(O2)C=C(OC3=O)C)[C@@H](CN4C=NC(N)=C5C4=NC=N5)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Aβ aggregation-IN-4 Related Classifications
HY-177854 Related Classifications
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