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Art. -Nr.: HY-108984

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BBMP

Name: BBMP
Brand: MedChemExpress
SKU: HY-108984
Availability: PreOrder

(Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone)

BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca²⁺-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 97120-13-3
Formel: C₁₂H₁₁BrN₂O₃S
Molecular Weight:343.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

BBMP Chemical Structure

CAS. Nr.: 97120-13-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

BBMP is effective in both swelling and membrane potential assays displaying pIC₅₀ values of 5.5 and 5.6, respectively. BBMP dose-dependently prevents DNA fragmentation induced by KCl 25/5 mM shift and serum deprivation in cerebellar granule neurons with a pIC₅₀ of 5.7. The inhibition of PTP-mediated cytochrome c release observed in isolated mitochondria at 10 and 100 μM may explain its neuroprotective properties in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 97120-13-3
Molecular Weight 343.20
Formel C₁₂H₁₁BrN₂O₃S
SMILES

O=C1C(Br)=C(S(=O)(CC2=CC=CC=C2)=O)C=NN1C
Synonyms

5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bruno Fuks, et al. In vitro properties of 5-(benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone: a novel permeability transition pore inhibitor. Eur J Pharmacol. 2005 Sep 5;519(1-2):24-30. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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