Bcl-2-IN-2
Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL.
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- CAS. Nr.: 2383085-86-5
- Formel: C48H57N7O7S
- Molecular Weight:876.07
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Bcl-2 0.034 nM (IC50) |
Bcl-xL 43 nM (IC50) |
Bcl-2-IN-2 inhibits mutant Bcl-2-G101V with an IC50 of 1.2 nM. Bcl-2-IN-2 inhibits RS4;11 cellular proliferation with an IC50 of 1.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2383085-86-5
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Molecular Weight 876.07
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Formel C48H57N7O7S
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SMILES
O=C(NS(=O)(C1=CC=C(NC[C@H]2CC[C@@](O)(C)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCC5(CC(N6CCC[C@H]6C7=C(CC)C=CC=C7)C5)CC4)C=C3OC8=CC(C=CN9)=C9N=C8
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Bcl-2-IN-2 Related Classifications
HY-131247 Related Classifications
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