BIM187
BIM187 is a Bombesin Receptor agonist that induces satiety. BIM187 significantly reduces short-term food intake in rats, but does not alter the total 6 h food intake of rats. BIM187 can be used in studies related to feeding behavior and satiety regulation in rats.
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- CAS. Nr.: 137734-88-4
- Formel: C53H76N14O10
- Molecular Weight:1069.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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![[D-Phe12,Leu14]-Bombesin](https://file.medchemexpress.com/product_pic/hy-103287.gif)
![[D-Phe12]-Bombesin](https://file.medchemexpress.com/product_pic/hy-103282.gif)
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, starting weight 150-170 g, experimental weight 190-210 g, maintained on 6-hour daily food access, fasted 18 hours prior to experiments)[1]
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Dosage:0.5 μg/kg; 1 μg/kg; 2 μg/kg; 4 μg/kg; 8 μg/kg; 16 μg/kg; 32 μg/kg
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Administration:i.p.; single dose
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Result:Exerted no meaningful 30-min feeding suppression at 0.5, 1, 2 μg/kg.
Markedly cut 30-min food intake at 4, 8, 16, 32 μg/kg with non-dose-dependent activity.
Suppressed 30-min feeding significantly at 4 μg/kg and left total 6-h intake unchanged versus control.
Lowered 30-min food intake at 32 μg/kg, reduced 60-min intake, with intact total 6-h feeding volume.
Retained full 30-min feeding suppression after co-administration with CCK antagonists BIM18216 (1 mg/kg) and Devazepide (HY-106301) (100 μg/kg).
Maintained unaltered 30-min anorectic action against bombesin antagonist BIM189 (20 μg/kg) at 4 μg/kg.
Chemical Information
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CAS. Nr. 137734-88-4
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Molecular Weight 1069.28
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Formel C53H76N14O10
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SMILES
C([C@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)N)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H](CC(C)C)C(N)=O)=O)CC(C)C)=O)=O)=O)C(C)C)=O)C)=O)C=3C=4C(NC3)=CC=CC4
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Sequence
{d-Phe}-Gln-Trp-Ala-Val-Gly-His-Leu-Leu-NH2
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Sequence Shortening
{d-Phe}-QWAVGHLL-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BIM187 Related Classifications
HY-103279 Related Classifications
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