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Art. -Nr.: HY-N19296

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Blapsin B

Blapsin B is a potent 14-3-3 inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC₅₀ value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research.

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CAS. Nr.: 861145-00-8
Formel: C₁₅H₁₄O₅
Molecular Weight:274.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Blapsin B Chemical Structure

CAS. Nr.: 861145-00-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Blapsin B (10 μM) potently inhibits 14-3-3γ protein-protein interactions in an ELISA assay with an IC₅₀ of 10.0 μM^[1].
Blapsin B (2.5 μM) potently inhibits 14-3-3 protein-protein interactions in an FP assay with an IC₅₀ of 2.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 861145-00-8
Molecular Weight 274.27
Formel C₁₅H₁₄O₅
SMILES

OC1=CC=C(C2OCCC3=CC(O)=C(C=C32)O)C=C1O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Animals
from the insect Blaps japanensis
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Yan YM, et al. Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. Bioorg Med Chem Lett. 2012;22(12):4179-4181. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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