Broquinaldol
Based on 1 Customer Validation
Broquinaldol, a brominated quinoline, is a potent antistaphylococcal agent. Broquinaldol is also a Mn(II) ionophore that can be used to synthesize metalloantibiotic.
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- Reinheit : 99.70%
- CAS. Nr.: 15599-52-7
- Formel: C10H7Br2NO
- Molecular Weight:316.98
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
22.47 μg/mL
Compound: 4
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Cytotoxicity against human HaCaT cells assessed as cell shrinkage after 24 hrs by SRB assay
Cytotoxicity against human HaCaT cells assessed as cell shrinkage after 24 hrs by SRB assay
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[PMID: 24269165] |
| HeLa | IC50 |
>100 μM
Compound: 29
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Cytotoxicity against human HeLa cells after 24 hrs by LDH release assay
Cytotoxicity against human HeLa cells after 24 hrs by LDH release assay
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[PMID: 27018907] |
| HeLa | IC50 |
>100 μM
Compound: HQ-1
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Cytotoxicity against human HeLa cells after 24 hrs by LDH release assay
Cytotoxicity against human HeLa cells after 24 hrs by LDH release assay
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[PMID: 29936357] |
In Vitro
Broquinaldol (compound 1) against Staphylococcus aureus and S. epidermidis strains with MIC values of 0.39-1.56 μM. Broquinaldol is capable of clearing established methicillin-resistant S. aureus, with an EC50 value of 2.6 μM, and S. epidermidis (EC50 = 9.2 μM) biofilms in crystal violet assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 15599-52-7
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Appearance Solid
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Molecular Weight 316.98
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Formel C10H7Br2NO
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Color Off-white to light brown
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SMILES
CC1=NC2=C(C=C1)C(=CC(=C2O)Br)Br
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (315.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Abouelhassan Y, et al. A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria. ChemMedChem. 2015 Jul;10(7):1157-62. [Content Brief]
[2]. Mudarmah K, et al. Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving-Williams Series to completely eradicate Staphylococcus aurous. Dalton Trans. 2023 Sep 13;52(35):12203-12207. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1548 mL | 15.7739 mL | 31.5477 mL | 78.8693 mL |
| 5 mM | 0.6310 mL | 3.1548 mL | 6.3095 mL | 15.7739 mL | |
| 10 mM | 0.3155 mL | 1.5774 mL | 3.1548 mL | 7.8869 mL | |
| 15 mM | 0.2103 mL | 1.0516 mL | 2.1032 mL | 5.2580 mL | |
| 20 mM | 0.1577 mL | 0.7887 mL | 1.5774 mL | 3.9435 mL | |
| 25 mM | 0.1262 mL | 0.6310 mL | 1.2619 mL | 3.1548 mL | |
| 30 mM | 0.1052 mL | 0.5258 mL | 1.0516 mL | 2.6290 mL | |
| 40 mM | 0.0789 mL | 0.3943 mL | 0.7887 mL | 1.9717 mL | |
| 50 mM | 0.0631 mL | 0.3155 mL | 0.6310 mL | 1.5774 mL | |
| 60 mM | 0.0526 mL | 0.2629 mL | 0.5258 mL | 1.3145 mL | |
| 80 mM | 0.0394 mL | 0.1972 mL | 0.3943 mL | 0.9859 mL | |
| 100 mM | 0.0315 mL | 0.1577 mL | 0.3155 mL | 0.7887 mL |
Broquinaldol Related Classifications
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