Dimercaprol
Based on 1 publication(s) in Google Scholar
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.01%
- CAS. Nr.: 59-52-9
- Formel: C3H8OS2
- Molecular Weight:124.23
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Speicherung:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dimercaprol
More
Biologische Aktivität
HIV[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
50.1 μM
Compound: Dimercaprol
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Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
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[PMID: 20966043] |
Dimercaprol (10-100 μM; 4 h) could significantly protect PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-12 cells
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Concentration:10, 25, 50 and 100 μM
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Incubation Time:4 h
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Result:Significantly protected PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (13 days old) injected with HgCl2[3]
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Dosage:12.5 mg/kg, 25 mg/kg, 50 mg/kg or 75 mg/kg
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Administration:Subcutaneous injection; once
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Result:Decreased the mercury contents in liver and kidney.
Chemical Information
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CAS. Nr. 59-52-9
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Appearance Liquid (Density: 1.239 g/cm3)
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Molecular Weight 124.23
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Formel C3H8OS2
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Color Colorless to light yellow
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SMILES
OCC(S)CS
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Synonyms
2,3-Dimercapto-1-propanol; Dithioglycerol
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling. [Abstract]2026 Mar 11;15(3):356. PMID: 41897502
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (402.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 16.67 mg/mL (134.19 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (804.96 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kubota S, et al. 2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. AIDS Res Hum Retroviruses. 1990 Jul;6(7):919-27. [Content Brief]
[2]. Ran Tian, et al. Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. J Neurochem. 2017 Jun;141(5):708-720. [Content Brief]
[3]. Taciane Roza, et al. 2,3-Dimercapto-1-propanol does not alter the porphobilinogen synthase inhibition but decreases the mercury content in liver and kidney of suckling rats exposed to HgCl2. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):302-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.0496 mL | 40.2479 mL | 80.4959 mL | 201.2396 mL |
| 5 mM | 1.6099 mL | 8.0496 mL | 16.0992 mL | 40.2479 mL | |
| 10 mM | 0.8050 mL | 4.0248 mL | 8.0496 mL | 20.1240 mL | |
| 15 mM | 0.5366 mL | 2.6832 mL | 5.3664 mL | 13.4160 mL | |
| 20 mM | 0.4025 mL | 2.0124 mL | 4.0248 mL | 10.0620 mL | |
| 25 mM | 0.3220 mL | 1.6099 mL | 3.2198 mL | 8.0496 mL | |
| 30 mM | 0.2683 mL | 1.3416 mL | 2.6832 mL | 6.7080 mL | |
| 40 mM | 0.2012 mL | 1.0062 mL | 2.0124 mL | 5.0310 mL | |
| 50 mM | 0.1610 mL | 0.8050 mL | 1.6099 mL | 4.0248 mL | |
| 60 mM | 0.1342 mL | 0.6708 mL | 1.3416 mL | 3.3540 mL | |
| 80 mM | 0.1006 mL | 0.5031 mL | 1.0062 mL | 2.5155 mL | |
| 100 mM | 0.0805 mL | 0.4025 mL | 0.8050 mL | 2.0124 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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