DuP-697
Based on 1 publication(s) in Google Scholar
DuP-697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX-2 inhibitor (IC50 of 10 nM and 800 nM for human COX-2 and COX-1, respectively). DuP-697 exerts antiproliferative (IC50 of 42.8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 inhibits prostaglandin synthesis and has anti-inflammatory, anticancer and antipyretic effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.79%
- CAS. Nr.: 88149-94-4
- Formel: C17H12BrFO2S2
- Molecular Weight:411.31
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DuP-697
More
Biologische Aktivität
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hCOX-2 10 nM (IC50) |
hCOX-1 800 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.002 μM
Compound: DuP-697
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In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
In vitro inhibition of PGE-2 produced by arachidonic acid-stimulated CHO cells stably expressing human Prostaglandin G/H synthase 2
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[PMID: 9873621] |
| CHO | IC50 |
0.002 μM
Compound: DuP-697
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In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-2
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10.1016/S0960-894X(96)00580-X |
| CHO | IC50 |
0.002 μM
Compound: DuP-697
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Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
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10.1016/S0960-894X(96)00582-3 |
| CHO | IC50 |
0.0021 μM
Compound: DuP-697
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Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 2
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10.1016/S0960-894X(96)00501-X |
| CHO | IC50 |
0.059 μM
Compound: DuP-697
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Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
Inhibition of PGE-2 production in arachidonic acid-stimulated CHO cells expressing human Prostaglandin G/H synthase 1
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10.1016/S0960-894X(96)00501-X |
| CHO | IC50 |
0.059 μM
Compound: DuP-697
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In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1
In vitro inhibition of the production of PGE-2 in arachidonic acid stimulated chinese hamster ovary (CHO) cells transfected with human cyclooxygenase-1
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10.1016/S0960-894X(96)00580-X |
| CHO | IC50 |
0.059 μM
Compound: DuP-697
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Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells
Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 1 in chinese hamster ovary (CHO) cells
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10.1016/S0960-894X(96)00582-3 |
| Sf21 | IC50 |
126.32 μM
Compound: Dup-697
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Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell
Inhibition of human recombinant COX2 expressed in baculovirus infected SF21 cell
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[PMID: 20974503] |
| Sf9 | IC50 |
0.005 μM
Compound: 1 (DuP-697)
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Inhibitory activity against human COX-2 expressed in baculovirus infected Sf9 cells
Inhibitory activity against human COX-2 expressed in baculovirus infected Sf9 cells
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10.1016/0960-894X(95)00359-2 |
| Sf9 | IC50 |
0.007 μM
Compound: DuP-697
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Inhibitory activity against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells
Inhibitory activity against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells
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10.1016/0960-894X(95)00564-A |
| Sf9 | IC50 |
0.6 μM
Compound: 1 (DuP-697)
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Inhibitory activity against human COX-1 expressed in baculovirus infected Sf9 cells
Inhibitory activity against human COX-1 expressed in baculovirus infected Sf9 cells
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10.1016/0960-894X(95)00359-2 |
| Sf9 | IC50 |
0.6 μM
Compound: DuP-697
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Inhibitory activity against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf9 cells
Inhibitory activity against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf9 cells
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10.1016/0960-894X(95)00564-A |
| U-937 | IC50 |
0.007 μM
Compound: DuP-697
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Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidonic acid conc.
Inhibition of Prostaglandin G/H synthase 1 was measured by the inhibition of PGE-2 produced by microsomes from U937 cells at subsaturating arachidonic acid conc.
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[PMID: 9873621] |
DuP-697 (0-100 nM; 24 hours; HT29 cells) treatment shows antiproliferative with an IC50 value of 42.8 nM[1].
DuP-697 (25-100 nM; 72 hours; HT29 cells) treatment causes concentration dependent apoptosis in HT29 cells. The percentage of UR (apoptosis portion) area increases gradually according to the concentration of DuP-697 from 7% in control group to 52% in 100 nM DuP-697[1].
DuP-697 in 100, 10 and 1 nM concentrations cause antiangiogenic effect. Antiangiogenic scores of DuP-697 are 1.2, 0.8 and 0.5, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 cells
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Concentration:0 nM, 12.5 nM, 25 nM, 50 nM, 100 nM
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Incubation Time:24 hours
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Result:Exhibited decreasing CI values in a concentration dependent manner. Showed statistically significant cytotoxic effect.
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Cell Line:HT29 cells
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Concentration:25 nM, 50 nM, 100 nM
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Incubation Time:72 hours
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Result:Caused concentration dependent apoptosis in HT29 cells.
DuP-697 is a moderate inhibitor of bull seminal vesicle prostaglandin (PG) synthesis (IC50 of 24 μM) and a potent inhibitor of rat brain PG synthesis (IC50 of 4.5 μM) but was ineffective against rat kidney PG synthesis (IC50 of 75 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 88149-94-4
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Appearance Solid
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Molecular Weight 411.31
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Formel C17H12BrFO2S2
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Color White to off-white
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SMILES
O=S(C1=CC=C(C2=C(C3=CC=C(F)C=C3)SC(Br)=C2)C=C1)(C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation. [Abstract]2025 Oct 16;188(21):5878-5894.e18. PMID: 40774253
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (243.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
DMF : ≥ 54 mg/mL (131.29 mM)
Ethanol : ≥ 7 mg/mL (17.02 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (283 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Altun A, et al. Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines. Asian Pac J Cancer Prev. 2014;15(7):3113-21. [Content Brief]
[2]. Gans KR, et al. Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J Pharmacol Exp Ther. 1990 Jul;254(1):180-7. [Content Brief]
[3]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 ( Pt 2):479-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMF / DMSO | 1 mM | 2.4313 mL | 12.1563 mL | 24.3126 mL | 60.7814 mL |
| 5 mM | 0.4863 mL | 2.4313 mL | 4.8625 mL | 12.1563 mL | |
| 10 mM | 0.2431 mL | 1.2156 mL | 2.4313 mL | 6.0781 mL | |
| 15 mM | 0.1621 mL | 0.8104 mL | 1.6208 mL | 4.0521 mL | |
| DMF / DMSO | 20 mM | 0.1216 mL | 0.6078 mL | 1.2156 mL | 3.0391 mL |
| 25 mM | 0.0973 mL | 0.4863 mL | 0.9725 mL | 2.4313 mL | |
| 30 mM | 0.0810 mL | 0.4052 mL | 0.8104 mL | 2.0260 mL | |
| 40 mM | 0.0608 mL | 0.3039 mL | 0.6078 mL | 1.5195 mL | |
| 50 mM | 0.0486 mL | 0.2431 mL | 0.4863 mL | 1.2156 mL | |
| 60 mM | 0.0405 mL | 0.2026 mL | 0.4052 mL | 1.0130 mL | |
| 80 mM | 0.0304 mL | 0.1520 mL | 0.3039 mL | 0.7598 mL | |
| 100 mM | 0.0243 mL | 0.1216 mL | 0.2431 mL | 0.6078 mL |
DuP-697 Related Classifications
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