(E)-Ajoene
Based on 1 Customer Validation
(E)-Ajoene is an organosulfur compound and a neuroprotective agent with oral activity. (E)-Ajoene attenuates ischemia/reperfusion-induced hyperactivity, neuronal death in the hippocampal CA1 region, reactive astrogliosis, and reactive microgliosis. (E)-Ajoene is the E isomer of Ajoene (HY-106784) found in oil-macerated garlic products. (E)-Ajoene can be used for research on transient forebrain ischemia.
The product specifications provided below refer solely to the active content of (E)-Ajoene.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 95%
- CAS. Nr.: 92284-99-6
- Formel: C9H14OS3
- Molecular Weight:234.40
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
The product specifications provided below refer solely to the active content of (E)-Ajoene.
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Fibroblast | IC50 |
17.6 μM
Compound: 1
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Anticancer activity against cobalt radiation CT-1 transformed fibroblasts
Anticancer activity against cobalt radiation CT-1 transformed fibroblasts
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[PMID: 18774712] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Mongolian gerbils (purchased from Japan SLC Inc.)[2]
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Dosage:25 mg/kg
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Administration:p.o.; single dose; 30 min before ischemic surgery
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Result:Increased locomotor activity by 2.4-fold compared to pre-ischemia levels 1 day after ischemia/reperfusion.
Preserved 18.7% of cresyl violet-positive neurons in the stratum pyramidale of the hippocampal CA1 region relative to the sham control group 5 days after ischemia/reperfusion.
Showed slightly lower GFAP immunoreactivity in CA1 region astrocytes compared to vehicle-treated animals.
Exhibited lower Iba-1 immunoreactivity in activated microglia aggregated in the stratum pyramidale compared to the vehicle-treated group.
Chemical Information
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CAS. Nr. 92284-99-6
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Appearance Liquid
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Molecular Weight 234.40
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Formel C9H14OS3
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Color Colorless to light yellow
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SMILES
O=S(C/C=C/SSCC=C)CC=C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Rakshit D, et al. The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential. ACS Chem Neurosci. 2023 Mar 15;14(6):1033-1044. [Content Brief]
[2]. Yoo DY, et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Oct;72:1-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(E)-Ajoene Related Classifications
HY-106784A Related Classifications
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