ARPC2 - actin related protein 2/3 complex subunit 2 Gene

Also Known as ARC34; PRO2446; p34-Arc; PNAS-139

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10109

About ARPC2

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,217,189-218,254,348 (from NCBI)

This gene has 18 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in lymph node (RPKM 92.4), bone marrow (RPKM 89.6) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

ARPC2 Products (4)

mRNA	Protein	Name
NM_152862.3	NP_690601.1	actin-related protein 2/3 complex subunit 2
XM_017003113.2	XP_016858602.1	actin-related protein 2/3 complex subunit 2 isoform X1
NM_005731.3	NP_005722.1	actin-related protein 2/3 complex subunit 2
XM_047442808.1	XP_047298764.1	actin-related protein 2/3 complex subunit 2 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11162547	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	18560548	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11741539	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	9230079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC2 Protein Structure

P34-Arc

0
100
200
300 a.a.

Protein Preferred Names	Protein Names
actin-related protein 2/3 complex subunit 2	ARP2/3 protein complex subunit 34 actin related protein 2/3 complex, subunit 2, 34kDa arp2/3 complex 34 kDa subunit testis tissue sperm-binding protein Li 53e

ARPC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ARPC2	O15144	CORO1B	Homo sapiens	Q9BR76	Pull Down	17350576
Intra	ARPC2	O15144	VCL	Homo sapiens	P18206	Anti Bait CoIP	12473693

Cross: Cross-species interaction Intra: Intraspecies interaction

ARPC2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82407	ARPC2 Antibody (YA2152)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P82407A	ARPC2 Antibody (YA2152)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Inclusion Conjunctivitis	Chlamydial Conjunctivitis Inclusion Blennorrhoea Paratrachoma Adult Inclusion Conjunctivitis Inclusion Blenorrhea Conjunctivitis, Inclusion Neonatal Chlamydial Conjunctivitis Inclusion Conjunctivitis Of The Adult Chronic Conjunctivitis Due To Chlamydia Trachomatis Inclusion Conjunctivitis Due To Chlamydia Trachomatis Acute Follicular Conjunctivitis, Chlamydial Adult Chlamydial Keratoconjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-114657A	Benproperine phosphate	Inhibitor	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01015	ARPC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01016	Arpc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01017	Arpc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARPC2	VGNC	VGNC:82525
Mus musculus	ARPC2	MGD	MGI:1923959
Rattus norvegicus	ARPC2	RGD	RGD:1305848
Macaca mulatta	ARPC2	VGNC	VGNC:70019
Bos taurus	ARPC2	VGNC	VGNC:55326
Others	ARPC2	NCBI