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NMU - neuromedin U Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10874

About NMU

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:55,595,231-55,636,793 (from NCBI)

This gene has 6 transcripts (splice variants) and 143 orthologues. Biased expression in esophagus (RPKM 5.6), skin (RPKM 5.5) and 6 other tissues.

Summary

This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]

NMU Products (3)

mRNA	Protein	Name
NM_001292045.2	NP_001278974.1	neuromedin-U isoform 2 precursor
NM_001292046.2	NP_001278975.1	neuromedin-U isoform 3 precursor
NM_006681.4	NP_006672.1	neuromedin-U isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables type 1 neuromedin U receptor binding	IDA IDA: Inferred from direct assay	10894543	GOA
enables type 2 neuromedin U receptor binding	IDA IDA: Inferred from direct assay	10894543	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	10894543	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMU Protein Structure

NMU

0
100
174 a.a.

Protein Preferred Names	Protein Names
neuromedin-U	neuromedin U precursor-related peptide/neuromedin U preproprotein

NMU Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NMU	P48645	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	NMU	P48645	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	NMU	P48645	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	NMU	P48645	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	NMU	P48645	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	NMU	P48645	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Prey Pooling	32296183
Intra	NMU	P48645	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	32296183
Intra	NMU	P48645	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Array	32296183
Intra	NMU	P48645	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	NMU	P48645	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	NMU	P48645	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	NMU	P48645	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	NMU	P48645	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	NMU	P48645	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	NMU	P48645	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	NMU	P48645	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	NMU	P48645	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	NMU	P48645	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	NMU	P48645	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	NMU	P48645	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	NMU	P48645	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	NMU	P48645	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	NMU	P48645	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	NMU	P48645	KRTAP10-6	Homo sapiens	P60371	Validated Y2H	32296183
Intra	NMU	P48645	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	NMU	P48645	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	NMU	P48645	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	NMU	P48645	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	NMU	P48645	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	NMU	P48645	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	NMU	P48645	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	NMU	P48645	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	NMU	P48645	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	NMU	P48645	PTGS1	Homo sapiens	P23219	Y2H Array	32814053
Intra	NMU	P48645	PTGS1	Homo sapiens	P23219	Validated Y2H	32814053
Intra	NMU	P48645	PTGS1	Homo sapiens	P23219	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Squamous Cell Papilloma	Papilloma Epidermoid Papilloma Papilloma, Squamous Cell
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-34758	N-Nitroso-N-methylurea		99.74%	Unkown
HY-P1238A	Neuromedin U, rat TFA		99.90%	Unkown
HY-N6629	3'-Methoxyflavonol		99.92%	Unkown
HY-P1238	Neuromedin U, rat		/	Unkown
HY-P5084	Neuromedin S (human)		/	Unkown
HY-RS09391	NMU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W717139	N-Nitroso-N-methylurea-d5		/	Unkown
HY-RS17526	Nmu Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23983	Nmu Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990173	Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1)		99.406%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NMU	VGNC	VGNC:32139
Mus musculus	NMU	MGD	MGI:1860476
Felis catus	NMU	VGNC	VGNC:78536
Macaca mulatta	NMU	VGNC	VGNC:100255
Rattus norvegicus	NMU	RGD	RGD:68388
Others	NMU	NCBI