OSBPL9 - oxysterol binding protein like 9 Gene
Also Known as ORP9; ORP-9
Species: Homo sapiens
About OSBPL9
This gene has 27 transcripts (splice variants), 220 orthologues and 11 paralogues. Ubiquitous expression in kidney (RPKM 20.1), thyroid (RPKM 18.0) and 25 other tissues.
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a Cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]
OSBPL9 Products (11)
| mRNA | Protein | Name |
|---|---|---|
| NM_001330580.2 | NP_001317509.1 | oxysterol-binding protein-related protein 9 isoform g |
| NM_001350208.2 | NP_001337137.1 | oxysterol-binding protein-related protein 9 isoform h |
| NM_001350209.2 | NP_001337138.1 | oxysterol-binding protein-related protein 9 isoform h |
| NM_001350210.2 | NP_001337139.1 | oxysterol-binding protein-related protein 9 isoform i |
| NM_024586.6 | NP_078862.4 | oxysterol-binding protein-related protein 9 isoform e |
| NM_148904.4 | NP_683702.1 | oxysterol-binding protein-related protein 9 isoform a |
| NM_148905.4 | NP_683703.1 | oxysterol-binding protein-related protein 9 isoform a |
| NM_148906.3 | NP_683704.2 | oxysterol-binding protein-related protein 9 isoform b |
| NM_148907.3 | NP_683705.1 | oxysterol-binding protein-related protein 9 isoform c |
| NM_148908.4 | NP_683706.3 | oxysterol-binding protein-related protein 9 isoform d |
| NM_148909.4 | NP_683707.3 | oxysterol-binding protein-related protein 9 isoform f |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19615732 | GOA |
OSBPL9 Protein Structure
PH: PH domain (4 - 97)
Oxysterol_BP: Oxysterol-binding protein (375 - 717)
- 0
- 200
- 400
- 600
- 736 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
oxysterol-binding protein-related protein 9 |
|
OSBPL9 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
OSBPL9 | Q96SU4 | OSBPL10 | Homo sapiens | Q9BXB5 | 19615732 | |
|
Intra
|
OSBPL9 | Q96SU4 | OSBPL11 | Homo sapiens | Q9BXB4 | 19615732 | |
|
Intra
|
OSBPL9 | Q96SU4 | OSBPL11 | Homo sapiens | Q9BXB4 | 20599956 | |
|
Intra
|
OSBPL9 | Q96SU4 | OSBPL11 | Homo sapiens | Q9BXB4 | 20599956 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lenz-Majewski Hyperostotic Dwarfism |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | OSBPL9 | VGNC | VGNC:63984 |
| Canis familiaris | OSBPL9 | VGNC | VGNC:44159 |
| Bos taurus | OSBPL9 | VGNC | VGNC:32467 |
| Rattus norvegicus | OSBPL9 | RGD | RGD:1311508 |
| Mus musculus | OSBPL9 | MGD | MGI:1923784 |
| Macaca mulatta | OSBPL9 | VGNC | VGNC:75625 |
| Others | OSBPL9 | NCBI |