OSBPL10 - oxysterol binding protein like 10 Gene

Also Known as ORP10; OSBP9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114884

About OSBPL10

Cytogenetic location: 3p23-p22.3 Genomic coordinates (GRCh38): 3:31,660,825-32,077,692 (from NCBI)

This gene has 20 transcripts (splice variants), 251 orthologues and 11 paralogues. Broad expression in testis (RPKM 5.3), placenta (RPKM 5.2) and 23 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

OSBPL10 Products (2)

mRNA Protein Name
NM_001174060.2 NP_001167531.1 oxysterol-binding protein-related protein 10 isoform 2
NM_017784.5 NP_060254.2 oxysterol-binding protein-related protein 10 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Referencias Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
17428193 GOA
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
23934110 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL10 Protein Structure

PH_8

PH_8: Pleckstrin homology domain (85 - 167)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (401 - 750)

  • 0
  • 200
  • 400
  • 600
  • 764 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein-related protein 10

  • ORP-10

OSBPL10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
OSBPL10 Q9BXB5 OSBPL9 Homo sapiens Q96SU4
BiFC
22906437
Intra
OSBPL10 Q9BXB5 OSBPL9 Homo sapiens Q96SU4
Anti Tag CoIP
22906437
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS09837 OSBPL10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OSBPL10 MGD MGI:1921736
Bos taurus OSBPL10 VGNC VGNC:32458
Macaca mulatta OSBPL10 VGNC VGNC:75629
Felis catus OSBPL10 VGNC VGNC:63976
Rattus norvegicus OSBPL10 RGD RGD:1561652
Canis familiaris OSBPL10 VGNC VGNC:44151
Others OSBPL10 NCBI