Fap - fibroblast activation protein Gene

Also Known as SIMP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14089

Summary

This gene belongs to the serine protease family. The encoded protein is an inducible cell-surface bound glycoprotein specifically expressed in tumor-associated fibroblasts and pericytes of epithelial tumors and has protease and gelatinase activity. The protein plays a role in remodeling of the extracellular matrix (ECM) and may affect tumorigenesis and tissue repair. Alternately spliced transcript variants of this gene are described in the literature (PMID 9139873), but the full-length sequence of these variants is not available. [provided by RefSeq, Apr 2013]

Fap Products (1)

mRNA Protein Name
NM_007986.3 NP_032012.1 prolyl endopeptidase FAP

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables peptidase activity IDA
IDA: Inferred from direct assay
9688278 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in melanocyte apoptotic process IDA
IDA: Inferred from direct assay
15133496 MGI
involved in melanocyte proliferation IDA
IDA: Inferred from direct assay
15133496 MGI
involved in negative regulation of cell proliferation involved in contact inhibition IDA
IDA: Inferred from direct assay
15133496 MGI
involved in positive regulation of execution phase of apoptosis IDA
IDA: Inferred from direct assay
15133496 MGI
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
15133496 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in apical part of cell IDA
IDA: Inferred from direct assay
24038871 MGI
located in basal part of cell IDA
IDA: Inferred from direct assay
24038871 MGI
located in cell surface IDA
IDA: Inferred from direct assay
15133496 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl endopeptidase FAP

  • FAPalpha

  • dipeptidyl peptidase FAP

  • fibroblast activation protein alpha

  • gelatine degradation protease FAP

  • integral membrane serine protease

  • post-proline cleaving enzyme

  • seprase

  • serine integral membrane protease

  • surface-expressed protease

Recombinant Fap Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77934 FAP Protein, Mouse (HEK293, His) P97321-1 (L26-D761) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P3392A Zilganersen sodium Inhibitor 91.43% Phase 3
HY-137331 Linofapib bentoxetan 99.02% Phase 2
HY-172317 AZD2389 Inhibitor 99.65% Phase 2
HY-147057A Rofapitide tetraxetan acetate / Phase 1
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99269 Sibrotuzumab 99.05% Phase 2

Pre-clinical Phase

Bioactive Molecules (76)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-147057 Rofapitide tetraxetan 99.89% Unkown
HY-128643 FAPI-4 99.47% Unkown
HY-100684 UAMC-1110 Inhibitor 99.51% Unkown
HY-101801 Ac-Gly-BoroPro 99.89% Unkown
HY-145983 Suc-Gly-Pro-AMC 99.85% Unkown
HY-147173 FAPI-74 99.84% Unkown
HY-153552A NH2-UAMC1110 TFA Inhibitor 99.98% Unkown
HY-145938 OncoFAP 99.77% Unkown
HY-P10944 Unlabeled FXX489 Ligand 99.25% Unkown
HY-160289 ARI-3144 Substrate 99.72% Unkown
HY-164725 FAPI-mFS Inhibitor 98.71% Unkown
HY-P10131 3BP-3940 99.49% Unkown
HY-164316 FT-FAPI-12_9 99.07% Unkown
HY-125366 ARI-3099 Inhibitor 99.95% Unkown
HY-47979 FAP-IN-2 Inhibitor 99.93% Unkown
HY-136641 NOTA-FAPI Inhibitor 99.66% Unkown
HY-P3441A 3BP-4089 TFA Inhibitor 99.27% Unkown
HY-D2363 DOTA.SA.FAPi TFA Inhibitor 99.26% Unkown
HY-P10945 FAP targeting peptide for FXX489 99.49% Unkown
HY-139401 FAPI-34 Ligand 98.04% Unkown
HY-161074 PNT6555 96.55% Unkown
HY-164364A DOTAGA.(SA.FAPi)2 TFA Inhibitor 97.51% Unkown
HY-177435 FAPI-800CW Inhibitor 99.40% Unkown
HY-47979A FAP-IN-2 TFA Inhibitor 99.92% Unkown
HY-175350 OncoFAP-GlyPro-MMAE Ligand 99.71% Unkown
HY-175613 DOTA-ALB-02 Ligand 99.71% Unkown
HY-153552 NH2-UAMC1110 Inhibitor 99.86% Unkown
HY-173374 DOTAGA-FAP-2286-ALB Inhibitor 99.29% Unkown
HY-P10945B Cys-FAP targeting peptide for FXX489 TFA 95.77% Unkown
HY-183513 L-Ala-BPA Substrate 98.0% Unkown
HY-128642 FAPI-2 98.94% Unkown
HY-164567 SID 125240931 98.75% Unkown
HY-164316A FT-FAPI-12_9 TFA 99.48% Unkown
HY-D2281 FAP Ligand 2 / Unkown
HY-159768A DOTAGA.Glu.(FAPi)2 Ligand / Unkown
HY-159934 QI-18 Inhibitor / Unkown
HY-175612 DOTA-ALB-01 Ligand / Unkown
HY-103323 Fas C-Terminal Tripeptide Inhibitor / Unkown
HY-148361 Fluorogen binding modulator-1 / Unkown
HY-164364B DOTAGA.(SA.FAPi)2 analogue TFA Inhibitor 99.38% Unkown
HY-184826 FAP Ligand-4 Inhibitor / Unkown
HY-175353 TriOncoFAP-GlyPro-MMAE / Unkown
HY-175322 FAPI-P8PN Inhibitor / Unkown
HY-182434 CL 118326 Antagonist / Unkown
HY-177459 DOTA-2P(FAPI)2 Inhibitor / Unkown
HY-182272 FAP-IN-9 Inhibitor / Unkown
HY-170779 DOTA-NI-FAPI-04 Inhibitor / Unkown
HY-P11602 DOTA-C1-FAP-2286 / Unkown
HY-174421 FAPI-JNU Ligand / Unkown
HY-P3392 Zilganersen 91.43% Unkown
HY-P11599 NOTA-SP2A-FAPT Ligand / Unkown
HY-177083 Faridoxorubicin Substrate / Unkown
HY-159771 FAP6-19 Ligand / Unkown
HY-128642A FAPI-2 TFA 99.40% Unkown
HY-172137 FAPI-FUSCC-07 Ligand / Unkown
HY-158326 FAP-IN-4 Inhibitor / Unkown
HY-175685 FAP-IN-7 Inhibitor / Unkown
HY-176958 OncoFAP-EN-DOTAGA Inhibitor / Unkown
HY-P3392C Zilganersen sodium scrambled negative control Inhibitor / Unkown
HY-146180 FSDD0I / Unkown
HY-146182 FSDD3I / Unkown
HY-175330 FAP-IN-6 Inhibitor / Unkown
HY-146181 FSDD1I / Unkown
HY-186190 I-FAPI-04 prodrug-1 Inhibitor / Unkown
HY-183796 GFAP/NF-κB/APOE/NLRP3-IN-1 Inhibitor / Unkown
HY-149860 FAP-IN-1 Inhibitor / Unkown
HY-P10945A Cys-FAP targeting peptide for FXX489 / Unkown
HY-173319 FAP-IN-5 Inhibitor / Unkown
HY-178981 FAP-IN-8 Inhibitor / Unkown
HY-182250 BR103354 Inhibitor / Unkown
HY-161262 SB03178 Inhibitor / Unkown
HY-P3441 3BP-4089 Inhibitor 99.27% Unkown
HY-181494 FAPI-X5 Inhibitor / Unkown
HY-181580 FAP Ligand 3 Ligand / Unkown
HY-163079 AlF-PD-FAPI / Unkown
HY-W668749 3BP-3580 Inhibitor / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990245 Anti-Mouse FAP Antibody (73.3) Inhibitor 95.00% Unkown
HY-P991995 OMTX005 Inhibitor 98.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fap NCBI NCBI:2191