1. Gene
  2. FAP - fibroblast activation protein alpha Gene

FAP - fibroblast activation protein alpha Gene

Homo sapiens

Also known as FAPA; SIMP; DPPIV; FAPalpha

Gene ID: 2191 | Gene type: protein coding

About FAP

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,170,684-162,243,445 (from NCBI)

This gene has 13 transcripts (splice variants), 127 orthologues and 6 paralogues. Biased expression in endometrium (RPKM 7.5), gall bladder (RPKM 5.1) and 11 other tissues.

Summary

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

FAP Products(2)

mRNA Protein Name
NM_001291807.3 NP_001278736.1 prolyl endopeptidase FAP isoform 2
NM_004460.5 NP_004451.2 prolyl endopeptidase FAP isoform 1

FAP Protein Structure

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (106 - 473)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (555 - 757)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
Protein Preferred Names Protein Names

prolyl endopeptidase FAP

170 kDa melanoma membrane-bound gelatinase

Recombinant FAP Proteins

Cat. No. Product Name Accession Purity
HY-P72659 FAP Protein, Human (HEK293, His) Q12884 (L26-D760) ≥95%
HY-P77521 FAP Protein, Human (Biotinylated, HEK293, His) Q12884 (L26-D760) ≥95%
HY-P78121 FAP Protein, Human (Biotinylated, HEK293, His-Avi) Q12884 (L26-D760) ≥95%

Related Diseases

Diseases Alias
Breast Ductal Carcinoma

Ductal Breast Carcinoma

Duct Carcinoma

Carcinoma, Ductal

Mammary Ductal Carcinoma

Ductal Carcinoma

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Glioma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FAP RGD RGD:621253
Bos taurus FAP VGNC VGNC:28862
Canis familiaris FAP VGNC VGNC:40727
Felis catus FAP VGNC VGNC:62146
Macaca mulatta FAP VGNC VGNC:72613
Mus musculus FAP MGD MGI:109608
Macaca fascicularis FAP NCBI
Others FAP NCBI