2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. ADC Antibody FAP
  4. OMTX005

OMTX005  (Synonyms: OMTX705 antibody)

Cat. No.: HY-P991995
Technical Support

OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research.

For research use only. We do not sell to patients.

OMTX005

OMTX005 Chemical Structure

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OMTX005 Related Antibodies

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Description

OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research[1].

Species Reactivity

Human
In Vitro

OMTX005 specifically binds to FAP-expressing HT1080-FAP cells and primary CAF07 cells, with EC50 values of 76 pM and 130 nM, respectively[1].
OMTX005 (5 days) does not reduce the viability of HT1080-WT, HT1080-FAP or primary CAF07 cells[1].
OMTX005 (400 nmol/L; 0-48 h) does not induce caspase 3/7 activity in HT1080-WT, HT1080-FAP or primary CAF07 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OMTX005 Related Antibodies

Cell Viability Assay[1]

Cell Line: HT1080-WT, HT1080-FAP, primary CAF07 cells
Concentration: up to 400 nmol/L
Incubation Time: 5 days
Result: Did not exhibit cytotoxic activity in any of the cell lines tested.
Gene ID

2191  [NCBI]

Accession
Target

FAP
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[OMTX005]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OMTX005 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OMTX005OMTX705 antibodyOMTX 005OMTX-005ADC AntibodyFAPFibroblast activation proteinpancreatic cancertriple-negative breast cancernon-small cell lung cancerhumancaspase 3/7murineintratumoral stromal cellsfibroblast-activating proteinPDX modelhumanized PDX modelsInhibitorinhibitorinhibit

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