2. Immunology/Inflammation
  3. FAP
  4. DOTA-ALB-02

DOTA-ALB-02 is an albumin-bound FAP inhibitor (FAPI) ligand. DOTA-ALB-02 labeled with 177Lu has a high FAP-binding affinity and enhanced tumor uptake and retention with a significant tumor/nontarget ratio. DOTA-ALB-02 can be used for PET/CT and SPECT/CT imaging of cancers, especially late-stage cancers.

For research use only. We do not sell to patients.

DOTA-ALB-02

DOTA-ALB-02 Chemical Structure

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Based on 1 publication(s) in Google Scholar

DOTA-ALB-02 Related Antibodies

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Description

DOTA-ALB-02 is an albumin-bound FAP inhibitor (FAPI) ligand. DOTA-ALB-02 labeled with 177Lu has a high FAP-binding affinity and enhanced tumor uptake and retention with a significant tumor/nontarget ratio. DOTA-ALB-02 can be used for PET/CT and SPECT/CT imaging of cancers, especially late-stage cancers[1].

Molecular Weight

1481.38

Formula

C64H91F2IN12O18
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCCC[C@@H](C(NC1=CC=CC2=C1N=CC=C2C(NCC(N3CC(C[C@H]3C#N)(F)F)=O)=O)=O)NC(CCCC4=CC=C(I)C=C4)=O)CCOCCOCCOCCOCCOCCOCCNC(CN5CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (67.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6750 mL 3.3752 mL 6.7505 mL
5 mM 0.1350 mL 0.6750 mL 1.3501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6750 mL 3.3752 mL 6.7505 mL 16.8762 mL
5 mM 0.1350 mL 0.6750 mL 1.3501 mL 3.3752 mL
10 mM 0.0675 mL 0.3375 mL 0.6750 mL 1.6876 mL
15 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1251 mL
20 mM 0.0338 mL 0.1688 mL 0.3375 mL 0.8438 mL
25 mM 0.0270 mL 0.1350 mL 0.2700 mL 0.6750 mL
30 mM 0.0225 mL 0.1125 mL 0.2250 mL 0.5625 mL
40 mM 0.0169 mL 0.0844 mL 0.1688 mL 0.4219 mL
50 mM 0.0135 mL 0.0675 mL 0.1350 mL 0.3375 mL
60 mM 0.0113 mL 0.0563 mL 0.1125 mL 0.2813 mL
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DOTA-ALB-02 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-ALB-02FAPFibroblast activation proteinAlbumin-boundFAP inhibitorFAPILigand177LuTumor/nontarget ratioPET/CTSPECT/CTLate-stage cancerInhibitorinhibitorinhibit

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