Top2b - topoisomerase (DNA) II beta Gene

Also Known as Top-2; D230016L12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21974

Summary

Predicted to enable several functions, including enzyme binding activity; protein C-terminus binding activity; and protein heterodimerization activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Located in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human TOP2B (DNA Topoisomerase II beta). [provided by Alliance of Genome Resources, Apr 2022]

Top2b Products (1)

mRNA Protein Name
NM_009409.3 NP_033435.2 DNA topoisomerase 2-beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IMP
IMP: Inferred from mutant phenotype
31409799 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21186367 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
31409799 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
10615047 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
12773624 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
12773624 MGI
Cellular Component GO Annotation Evidence Verweise Source
NOT located in chromosome IDA
IDA: Inferred from direct assay
11835579 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9224616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA topoisomerase 2-beta

  • DNA topoisomerase II, beta isozyme

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-174374 Topobexin Inhibitor 99.04% Unkown
HY-123393 PNU-142586 Inhibitor 97.92% Unkown
HY-RS14897 TOP2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175834 DNA/TOP2A-IN-1 / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown
HY-RS20119 Top2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26623 Top2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top2b NCBI NCBI:7155