RNF152 - ring finger protein 152 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 220441

About RNF152

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:61,808,067-61,894,412 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 12 paralogues. Biased expression in kidney (RPKM 29.4), liver (RPKM 4.9) and 13 other tissues.

Summary

Enables small GTPase binding activity and ubiquitin protein Ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein polyubiquitination. Located in lysosomal membrane. Is integral component of organelle membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF152 Products (1)

mRNA Protein Name
NM_173557.3 NP_775828.1 E3 ubiquitin-protein ligase RNF152

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
25936802 GOA
enables ubiquitin protein ligase activity EXP
EXP: Inferred from Experiment
25936802 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
30514904 GOA
enables ubiquitin protein ligase activity IMP
IMP: Inferred from mutant phenotype
25936802 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
21203937 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to amino acid starvation IDA
IDA: Inferred from direct assay
25936802 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
25936802 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
25936802 GOA
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25936802 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
21203937 GOA
involved in protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
25936802 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
30514904 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
25936802 GOA
located in lysosome IDA
IDA: Inferred from direct assay
21203937 GOA
located in organelle membrane IMP
IMP: Inferred from mutant phenotype
25936802 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF152 Protein Structure

zf-RING_5

zf-RING_5: zinc-RING finger domain (11 - 55)

  • 0
  • 100
  • 203 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF152

  • RING-type E3 ubiquitin transferase RNF152

RNF152 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RNF152 Q8N8N0 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
RNF152 Q8N8N0 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
RNF152 Q8N8N0 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
RNF152 Q8N8N0 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
RNF152 Q8N8N0 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
RNF152 Q8N8N0 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
RNF152 Q8N8N0 LITAF Homo sapiens Q99732
Y2H Array
32814053
Intra
RNF152 Q8N8N0 LITAF Homo sapiens Q99732
Validated Y2H
32814053
Intra
RNF152 Q8N8N0 LITAF Homo sapiens Q99732
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12059 RNF152 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RNF152 VGNC VGNC:104245
Rattus norvegicus RNF152 RGD RGD:1305251
Canis familiaris RNF152 VGNC VGNC:45641
Bos taurus RNF152 VGNC VGNC:106897
Mus musculus RNF152 MGD MGI:2443787
Felis catus RNF152 VGNC VGNC:64676
Others RNF152 NCBI