DAAM1 - dishevelled associated activator of morphogenesis 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23002

About DAAM1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,188,667-59,371,405 (from NCBI)

This gene has 13 transcripts (splice variants), 238 orthologues and 18 paralogues. Ubiquitous expression in skin (RPKM 17.9), esophagus (RPKM 12.9) and 25 other tissues.

Summary

Cell motility, adhesion, cytokinesis, and Other functions of the cell cortex are mediated by reorganization of the actin Cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

DAAM1 Products (2)

mRNA	Protein	Name
NM_001270520.2	NP_001257449.1	disheveled-associated activator of morphogenesis 1 isoform 2
NM_014992.2	NP_055807.1	disheveled-associated activator of morphogenesis 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16630611	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16630611	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	26644512	GOA
located in motile cilium	IDA IDA: Inferred from direct assay	26644512	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	20534871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAAM1 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1078 a.a.

Protein Preferred Names	Protein Names
disheveled-associated activator of morphogenesis 1

DAAM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DAAM1	Q9Y4D1	INTU	Homo sapiens	Q9ULD6	Anti Tag CoIP	26644512
Intra	DAAM1	Q9Y4D1	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	18218625
Intra	DAAM1	Q9Y4D1	RHOC	Homo sapiens	P08134	Pull Down	18218625
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	Anti Bait CoIP	18218625
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	Pull Down	18218625
Intra	DAAM1	Q9Y4D1	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	16630611
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	PLA	25241761
Intra	DAAM1	Q9Y4D1	TRIP10	Homo sapiens	Q15642-2	Anti Tag CoIP	16630611
Intra	DAAM1	Q9Y4D1	TRIP10	Homo sapiens	Q15642-2	Pull Down	16630611
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	SPR	18218625
Cross	DAAM1	Q9Y4D1	SRC	Gallus gallus	P00523	Pull Down	16630611
Cross	DAAM1	Q9Y4D1	SRC	Gallus gallus	P00523	Anti Bait CoIP	16630611

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cerebral Amyloid Angiopathy, Itm2b-Related, 2	Dementia, Familial Danish Fdd Familial Danish Dementia Heredopathia Ophthalmootoencephalica Hooe Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis Adan Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy 2 Itm2b Amyloidosis Familial Cerebral Amyloid Angiopathy Itm2b-Related Amyloidosis Itm2b-Related Cerebral Amyloid Angiopathy Familial Dementia, Danish Type Cerebral Amyloid Angiopathy, Itm2b-Related 2 CAA-ITM2B2 Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis Dementia, Familial, Danish
Gastric Tubular Adenocarcinoma	Tubular Adenocarcinoma Of Stomach
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03508	DAAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20899	Daam1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27416	Daam1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAAM1	VGNC	VGNC:27862
Macaca mulatta	DAAM1	VGNC	VGNC:71657
Canis familiaris	DAAM1	VGNC	VGNC:39756
Mus musculus	DAAM1	MGD	MGI:1914596
Felis catus	DAAM1	VGNC	VGNC:61326
Rattus norvegicus	DAAM1	RGD	RGD:1305119
Others	DAAM1	NCBI