RHOC - ras homolog family member C Gene

Also Known as H9; ARH9; ARHC; RHOH9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 389

About RHOC

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,701,131-112,707,408 (from NCBI)

This gene has 19 transcripts (splice variants), 257 orthologues and 22 paralogues. Ubiquitous expression in colon (RPKM 99.1), small intestine (RPKM 91.0) and 24 other tissues.

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

RHOC Products (3)

mRNA	Protein	Name
NM_001042678.2	NP_001036143.1	rho-related GTP-binding protein RhoC precursor
NM_001042679.2	NP_001036144.1	rho-related GTP-binding protein RhoC precursor
NM_175744.5	NP_786886.1	rho-related GTP-binding protein RhoC precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apical junction assembly	IDA IDA: Inferred from direct assay	20974804	GOA
involved in mitotic cytokinesis	IDA IDA: Inferred from direct assay	16236794	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20232393	GOA
involved in positive regulation of lipase activity	IDA IDA: Inferred from direct assay	19887681	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20232393	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cleavage furrow	IDA IDA: Inferred from direct assay	16236794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOC Protein Structure

Ras

0
100
193 a.a.

Protein Preferred Names	Protein Names
rho-related GTP-binding protein RhoC	RAS-related homolog 9

RHOC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHOC	P08134	RIPOR3	Homo sapiens	Q96MK2	Validated Y2H	32296183
Intra	RHOC	P08134	RIPOR2	Homo sapiens	Q9Y4F9	Y2H Prey Pooling	25416956
Intra	RHOC	P08134	DAAM1	Homo sapiens	Q9Y4D1	Anti Tag CoIP	33961781
Intra	RHOC	P08134	DIAPH1	Homo sapiens	O60610	Pull Down	18218625
Intra	RHOC	P08134	DIAPH1	Homo sapiens	O60610	Anti Tag CoIP	33961781
Intra	RHOC	P08134	ARHGAP1	Homo sapiens	Q07960	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

RHOC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87061	Rho A+B+C Antibody (YA6754)	WB, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases	Alias
Inflammatory Breast Carcinoma	Inflammatory Breast Cancer Inflammatory Carcinoma Of Breast Mastitis Carcinomatosa Breast Cancer, Inflammatory Inflammatory Breast Neoplasms Inflammatory Adenocarcinoma Of Breast
Breast Disease	Breast Diseases
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11950	RHOC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19377	Rhoc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25869	Rhoc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RHOC	RGD	RGD:1304965
Mus musculus	RHOC	MGD	MGI:106028
Bos taurus	RHOC	VGNC	VGNC:55672
Others	RHOC	NCBI