PDS5B - PDS5 cohesin associated factor B Gene

Also Known as AS3; APRIN; CG008

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23047

About PDS5B

Cytogenetic location: 13q13.1 Genomic coordinates (GRCh38): 13:32,586,452-32,778,019 (from NCBI)

This gene has 9 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 8.3), endometrium (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during Mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

PDS5B Products (1)

mRNA Protein Name
NM_015032.4 NP_055847.1 sister chromatid cohesion protein PDS5 homolog B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA binding IDA
IDA: Inferred from direct assay
19412548 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15837422 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in mitotic sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
15855230 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10963680 GOA
acts upstream of or within regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10963680 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in chromatin IDA
IDA: Inferred from direct assay
16682347 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sister chromatid cohesion protein PDS5 homolog B

  • androgen induced inhibitor of proliferation

PDS5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PDS5B Q9NTI5 WAPL Homo sapiens Q7Z5K2
Cosedimentation
17113138
Intra
PDS5B Q9NTI5 WAPL Homo sapiens Q7Z5K2
Anti Bait CoIP
17112726
Intra
PDS5B Q9NTI5 WAPL Homo sapiens Q7Z5K2
Anti Bait CoIP
17113138
Intra
PDS5B Q9NTI5 STAG2 Homo sapiens Q8N3U4
Anti Bait CoIP
17113138
Intra
PDS5B Q9NTI5 STAG1 Homo sapiens Q8WVM7
Anti Bait CoIP
15855230
Intra
PDS5B Q9NTI5 STAG1 Homo sapiens Q8WVM7
Anti Bait CoIP
17113138
Intra
PDS5B Q9NTI5 BRCA2 Homo sapiens P51587
Anti Tag CoIP
22293751
Intra
PDS5B Q9NTI5 BRCA2 Homo sapiens P51587
Anti Bait CoIP
22293751
Intra
PDS5B Q9NTI5 BRCA2 Homo sapiens P51587
Y2H
22293751
Intra
PDS5B Q9NTI5 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
17113138
Intra
PDS5B Q9NTI5 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
22293751
Intra
PDS5B Q9NTI5 SMC3 Homo sapiens Q9UQE7
Anti Bait CoIP
15855230
Intra
PDS5B Q9NTI5 RAD21 Homo sapiens O60216
Anti Bait CoIP
17112726
Intra
PDS5B Q9NTI5 RAD21 Homo sapiens O60216
Anti Bait CoIP
15855230
Intra
PDS5B Q9NTI5 RAD21 Homo sapiens O60216
Anti Bait CoIP
17113138
Intra
PDS5B Q9NTI5 RAD21 Homo sapiens O60216
Anti Bait CoIP
22293751
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Anemia Of Prematurity
Roberts-Sc Phocomelia Syndrome

  • Roberts Syndrome

  • Sc Phocomelia Syndrome

  • RBS

  • Long Bone Deficiencies Associated With Cleft Lip-Palate

  • Sc Pseudothalidomide Syndrome

  • Appelt-Gerken-Lenz Syndrome

  • Pseudothalidomide Syndrome

  • Tetraphocomelia-Cleft Palate Syndrome

  • Hypomelia Hypotrichosis Facial Hemangioma Syndrome

  • Roberts Syndrome/Sc Phocomelia

  • Roberts Tetraphocomelia Syndrome

  • Sc Syndrome

  • Sc Phocomelia

  • Sc Disease

  • Sc

  • Hemoglobin Sc Disease
Pseudohypoparathyroidism, Type Ib

  • Pseudohypoparathyroidism Type 1b

  • PHP1B

  • Pseudohypoparathyroidism Ib

  • Pseudohypoparathyroidism Type Ib

  • Php Ib

  • Pseudohypoparathyroidism 1b
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10292 PDS5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDS5B VGNC VGNC:44393
Felis catus PDS5B VGNC VGNC:64098
Macaca mulatta PDS5B VGNC VGNC:75835
Mus musculus PDS5B MGD MGI:2140945
Bos taurus PDS5B VGNC VGNC:32718
Rattus norvegicus PDS5B RGD RGD:1310838
Others PDS5B NCBI