TNRC6B - trinucleotide repeat containing adaptor 6B Gene
Also Known as GDSBA
Species: Homo sapiens
About TNRC6B
This gene has 9 transcripts (splice variants), 293 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 3.9), thyroid (RPKM 2.3) and 25 other tissues.
Summary
Enables RNA binding activity. Involved in regulation of gene expression. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Implicated in subserous uterine fibroid and uterine fibroid. [provided by Alliance of Genome Resources, Apr 2022]
TNRC6B Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001024843.2 | NP_001020014.1 | trinucleotide repeat-containing gene 6B protein isoform 3 |
| NM_001162501.2 | NP_001155973.1 | trinucleotide repeat-containing gene 6B protein isoform 1 |
| NM_015088.3 | NP_055903.2 | trinucleotide repeat-containing gene 6B protein isoform 2 |
TNRC6B Protein Structure
Ago_hook: Argonaute hook (940 - 1061)
RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (1664 - 1718)
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- 1833 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
trinucleotide repeat-containing gene 6B protein |
|
TNRC6B Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
TNRC6B | Q9UPQ9 | CNOT1 | Homo sapiens | A5YKK6 | 21981923 | |
|
Intra
|
TNRC6B | Q9UPQ9 | CNOT1 | Homo sapiens | A5YKK6 | 21981923 | |
|
Intra
|
TNRC6B | Q9UPQ9 | PAN3 | Homo sapiens | Q58A45 | 21981923 | |
|
Intra
|
TNRC6B | Q9UPQ9 | AGO2 | Homo sapiens | Q9UKV8 | 24043833 | |
|
Intra
|
TNRC6B | Q9UPQ9 | AGO2 | Homo sapiens | Q9UKV8 | 24043833 | |
|
Intra
|
TNRC6B | Q9UPQ9 | AGO2 | Homo sapiens | Q9UKV8 | 24043833 | |
|
Intra
|
TNRC6B | Q9UPQ9 | AGO2 | Homo sapiens | Q9UKV8 | 24043833 | |
|
Intra
|
TNRC6B | Q9UPQ9 | AGO2 | Homo sapiens | Q9UKV8 | 24043833 | |
|
Intra
|
TNRC6B | Q9UPQ9 | PABPC1 | Homo sapiens | P11940 | 21063388 | |
|
Intra
|
TNRC6B | Q9UPQ9 | PABPC1 | Homo sapiens | P11940 | 21981923 | |
|
Cross
|
TNRC6B | Q9UPQ9 | pAbp | Drosophila melanogaster | P21187 | 21063388 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Global Developmental Delay With Speech And Behavioral Abnormalities |
|
|
| Non-Specific Syndromic Intellectual Disability |
|
|
| Subserous Uterine Fibroid |
|
|
| Autism |
|
|
| Rectum Adenocarcinoma |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Coffin-Siris Syndrome 1 |
|
|
| Strabismus |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | TNRC6B | VGNC | VGNC:36205 |
| Macaca mulatta | TNRC6B | VGNC | VGNC:79786 |
| Felis catus | TNRC6B | VGNC | VGNC:66434 |
| Rattus norvegicus | TNRC6B | RGD | RGD:621428 |
| Canis familiaris | TNRC6B | VGNC | VGNC:82302 |
| Mus musculus | TNRC6B | MGD | MGI:2443730 |
| Others | TNRC6B | NCBI |