Grm5 - glutamate metabotropic receptor 5 Gene

Also Known as mGluR5; mGlur5

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24418

About Grm5

Primary_assembly 1: 141,312,368-141,882,274 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 11 phenotypes. Restricted expression toward (RPKM 246.3).

Summary

Enables A2A Adenosine Receptor binding activity; glutamate receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and trans-synaptic signaling. Located in astrocyte projection; dendrite; and postsynaptic density membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 Products (1)

mRNA Protein Name
NM_017012.2 NP_058708.1 metabotropic glutamate receptor 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables A2A adenosine receptor binding IPI
IPI: Inferred from physical interaction
12189203 RGD
enables glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
1320017 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12189203 RGD
enables protein tyrosine kinase activator activity IGI
IGI: Inferred from genetic interaction
24012003 RGD
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
24012003 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in G protein-coupled glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
1320017 RGD
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12514208 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12514208 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15758184 RGD
involved in positive regulation of long-term neuronal synaptic plasticity IDA
IDA: Inferred from direct assay
12740378 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15758184 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12189203 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in astrocyte projection IDA
IDA: Inferred from direct assay
21753079 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
18582438 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
18582438 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8758956 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
15829628 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15829628 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
8758956 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm5 Protein Structure

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (25 - 495)

NCD3G

NCD3G: pfam07562 (506 - 556)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 601)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (576 - 825)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (613 - 634)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (643 - 667)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (691 - 711)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (734 - 760)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (768 - 791)

7tmC_mGluR5

7tmC_mGluR5: cd15450 (794 - 819)

Herpes_BLLF1

Herpes_BLLF1: cl37540 (1012 - 1170)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1152 - 1202)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1203 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 5

  • glutamate receptor, metabotropic 5

  • metabotropic glutamate receptor (mGluR5)

  • metabotropic glutamate receptor 5b

Grm5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Grm5 P31424 Tamalin Rattus norvegicus Q8R4T5
SPR
17396155
Intra
Grm5 P31424 Tamalin Rattus norvegicus Q8R4T5
Anti Tag CoIP
17396155
Intra
Grm5 P31424 Ppp1cc Rattus norvegicus P63088
CoIP
14519764
Intra
Grm5 P31424 Ppp1cc Rattus norvegicus P63088
Pull Down
14519764
Intra
Grm5 P31424 Ppp1cc Rattus norvegicus P63088
Y2H
14519764
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05831 GRM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05832 Grm5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05833 Grm5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm5 NCBI NCBI:2915