ZDHHC5 - zinc finger DHHC-type palmitoyltransferase 5 Gene

Also Known as DHHC5; ZNF375

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25921

About ZDHHC5

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,668,114-57,701,182 (from NCBI)

This gene has 8 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 30.1), thyroid (RPKM 23.7) and 25 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in positive regulation of pattern recognition receptor signaling pathway and positive regulation of protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in phagocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC5 Products (1)

mRNA Protein Name
NM_015457.3 NP_056272.2 palmitoyltransferase ZDHHC5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables palmitoyltransferase activity IDA
IDA: Inferred from direct assay
22325201 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31402609 GOA
enables protein-cysteine S-palmitoyltransferase activity IDA
IDA: Inferred from direct assay
29185452 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
38092000 GOA
involved in positive regulation of pattern recognition receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31649195 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
31649195 GOA
involved in positive regulation of pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
38530158 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
31649195 GOA
acts upstream of or within protein palmitoylation IDA
IDA: Inferred from direct assay
22325201 GOA
involved in protein palmitoylation IDA
IDA: Inferred from direct assay
23034182 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
31649195 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16647879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC5 Protein Structure

DHHC

DHHC: DHHC palmitoyltransferase (62 - 222)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
Protein Preferred Names Protein Names

palmitoyltransferase ZDHHC5

  • DHHC-5

ZDHHC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ZDHHC5 Q9C0B5 GOLGA7B Homo sapiens Q2TAP0
Anti Tag CoIP
31402609
Intra
ZDHHC5 Q9C0B5 GOLGA7B Homo sapiens Q2TAP0
Confocal
31402609
Cross
ZDHHC5 Q9C0B5 S SARS-CoV-2 P0DTC2
Anti Tag CoIP
34117209
Cross
ZDHHC5 Q9C0B5 S SARS-CoV-2 P0DTC2
Y2H Array
36217030
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Acinar Adenocarcinoma

  • Acinar Adenocarcinoma Of The Lung
Lung Papillary Adenocarcinoma

  • Papillary Lung Adenocarcinoma

  • Papillary Adenocarcinoma Of The Lung
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS16022 ZDHHC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21221 Zdhhc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27737 Zdhhc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZDHHC5 MGD MGI:1923573
Bos taurus ZDHHC5 VGNC VGNC:37143
Macaca mulatta ZDHHC5 VGNC VGNC:79145
Felis catus ZDHHC5 VGNC VGNC:67216
Rattus norvegicus ZDHHC5 RGD RGD:1589737
Others ZDHHC5 NCBI