TLX1 - T cell leukemia homeobox 1 Gene

Also Known as TCL3; HOX11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3195

About TLX1

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:101,131,300-101,137,789 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues, 42 paralogues and is associated with 46 phenotypes. Biased expression in spleen (RPKM 14.4) and salivary gland (RPKM 3.2).

Summary

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

TLX1 Products (2)

mRNA Protein Name
NM_001195517.2 NP_001182446.1 T-cell leukemia homeobox protein 1 isoform 2
NM_005521.4 NP_005512.1 T-cell leukemia homeobox protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
19559479 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLX1 Protein Structure

Homeobox

Homeobox: Homeobox domain (202 - 258)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

T-cell leukemia homeobox protein 1

  • T-cell leukemia/lymphoma protein 3

TLX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TLX1 P31314 MEIS1 Homo sapiens O00470
Y2H
19559479
Intra
TLX1 P31314 MEIS1 Homo sapiens O00470
Anti Tag CoIP
19559479
Intra
TLX1 P31314 PBX2 Homo sapiens P40425
Affinity Chrom
35140242
Cross
TLX1 P31314 Ets1 Mus musculus P27577
Pull Down
22516263
Intra
TLX1 P31314 PBX1 Homo sapiens P40424-2
Anti Tag CoIP
19559479
Intra
TLX1 P31314 PBX1 Homo sapiens P40424-2
Y2H
19559479
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Childhood Acute Lymphocytic Leukemia

  • Childhood Acute Lymphoblastic Leukemia

  • Childhood All

  • Pediatric Acute Lymphoblastic Leukemia

  • Lymphoblastic Leukemia Acute Childhood
Epilepsy, Familial Temporal Lobe, 4

  • ETL4

  • Epilepsy, Occipitotemporal Lobe, And Migraine With Aura

  • Epolm

  • Familial Temporal Lobe Epilepsy 4

  • Occipitotemporal Lobe Epilepsy And Migraine With Aura
B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1

  • B-All With Etv6-Runx1

  • B-Lymphoblastic Leukemia/Lymphoma With T(12

  • 21)(P13.2

  • Q22.1)

  • Etv6-Runx1

  • B Lymphoblastic Leukemia/Lymphoma With T(12

  • 21)(P13.2

  • Q22.1)

  • Etv6-Runx1
Childhood T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Childhood Acute Lymphoblastic Leukemia

  • Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T-Cell Childhood Acute Lymphocytic Leukemia

  • Childhood T Lymphoblastic Leukemia/Lymphoma
Adult Acute Lymphocytic Leukemia

  • Adult Acute Lymphoid Leukemia

  • Adult All
Split Hand-Foot Malformation

  • Ectrodactyly

  • Split-Hand/Foot Malformation

  • Lobster-Claw Deformity

  • Split-Hand Deformity

  • Split Hand Foot Malformation

  • Shfm

  • Split Hand Foot Deformity

  • Split Hand Foot Deformity 1
Right Atrial Isomerism

  • Ivemark Syndrome

  • Asplenia With Cardiovascular Anomalies

  • RAI

  • Asplenia Syndrome

  • Asplenia

  • Right Isomerism

  • Splenic Agenesis Syndrome

  • Bilateral Right-Sidedness Sequence

  • Right Sided Atrial Isomerism

  • Isomerism Of Right Atrial Appendage

  • Heterotaxy, Visceroatrial, Autosomal Recessive

  • Polyasplenia

  • Vah, Autosomal Recessive

  • Atrial Isomerism, Right

  • Congenital Absence Of Spleen

  • Bilateral Right-Sidedness
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14602 TLX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TLX1 MGD MGI:98769
Rattus norvegicus TLX1 RGD RGD:1563655