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LCP2 - lymphocyte cytosolic protein 2 Gene

Also Known as IMD81; SLP76; SLP-76

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3937

About LCP2

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,246,233-170,297,777 (from NCBI)

This gene has 9 transcripts (splice variants), 232 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 53.7), appendix (RPKM 44.7) and 19 other tissues.

Summary

This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

LCP2 Products (1)

mRNA	Protein	Name
NM_005565.5	NP_005556.1	lymphocyte cytosolic protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8673706	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	20551903	GOA
involved in positive regulation of protein kinase activity	IEP IEP: Inferred from expression pattern	14624253	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of TCR signalosome	IDA IDA: Inferred from direct assay	20551903	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20551903	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	20551903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCP2 Protein Structure

SAM_2

SH2

0
100
200
300
400
500
533 a.a.

Protein Preferred Names	Protein Names
lymphocyte cytosolic protein 2	76 kDa tyrosine phosphoprotein

LCP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	LCP2	Q13094	ELOVL6	Homo sapiens	Q9H5J4	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	ELOVL6	Homo sapiens	Q9H5J4	Y2H Array	32296183
Intra	LCP2	Q13094	ELOVL6	Homo sapiens	Q9H5J4	Validated Y2H	32296183
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Pull Down	9207119
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	CoIP	10570256
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	CoIP	10671560
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Anti Bait CoIP	20534575
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Pull Down	10671560
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Validated Y2H	25814554
Intra	LCP2	Q13094	FYB1	Homo sapiens	O15117	Y2H Array	25814554
Intra	LCP2	Q13094	MAP4K3	Homo sapiens	Q8IVH8	Anti Bait CoIP	21983831
Intra	LCP2	Q13094	MAP4K3	Homo sapiens	Q8IVH8	Anti Tag CoIP	21983831
Intra	LCP2	Q13094	CD6	Homo sapiens	P30203	Anti Bait CoIP	24584089
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Peptide Array	17235283
Intra	LCP2	Q13094	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Anti Tag CoIP	21725281
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	CoIP	10229072
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	ITC	20562827
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	SLC	31467278
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Complementation	31467278
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Pull Down	15929943
Intra	LCP2	Q13094	NCK1	Homo sapiens	P16333	Solution Sedimentation	20562827
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Pull Down	15929943
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Peptide Array	17235283
Intra	LCP2	Q13094	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	LCP2	Q13094	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	LCP2	Q13094	VAV1	Homo sapiens	P15498	Pull Down	10347175
Intra	LCP2	Q13094	VAV1	Homo sapiens	P15498	Pull Down	8673706
Intra	LCP2	Q13094	VAV1	Homo sapiens	P15498	Anti Tag CoIP	21725281
Cross	LCP2	Q13094	Grap2	Mus musculus	O89100	SLCA	12773374
Cross	LCP2	Q13094	Grap2	Mus musculus	O89100	X-Ray Diffraction	16511262
Cross	LCP2	Q13094	Grap2	Mus musculus	O89100	ITC	12773374
Intra	LCP2	Q13094	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	LCP2	Q13094	NCK2	Homo sapiens	O43639	Anti Tag CoIP	25416956
Intra	LCP2	Q13094	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	LCP2	Q13094	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	LCP2	Q13094	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	BFG-2H	27107012
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Pull Down	15929943
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Y2H Pooling	16189514
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Y2H	21516116
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Validated Y2H	27107012
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	25416956
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Validated Y2H	25416956
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	Anti Bait CoIP	20534575
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	ITC	17235283
Intra	LCP2	Q13094	GRAP2	Homo sapiens	O75791	SPR	17235283
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Array	31515488
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	LCP2	Q13094	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	LCP2	Q13094	STAM	Homo sapiens	Q92783	Peptide Array	17235283
Intra	LCP2	Q13094	PLCG1	Homo sapiens	P19174	Pull Down	15929943
Intra	LCP2	Q13094	PLCG1	Homo sapiens	P19174	Anti Tag CoIP	21725281
Intra	LCP2	Q13094	ITK	Homo sapiens	Q08881	Anti Tag CoIP	21725281
Intra	LCP2	Q13094	ITK	Homo sapiens	Q08881	Anti Bait CoIP	10556826
Cross	LCP2	Q13094	PLCG1	Bos taurus	P08487	IF	16467851

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LCP2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71320	SLP-76 Protein, Human (His-T7)	Q13094 (M1-P533)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Immunodeficiency 81	IMD81
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Agammaglobulinemia 4, Autosomal Recessive	Agammaglobulinemia 4 AGM4 Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect B Cell Linker Protein Deficiency B-Cell Linker Protein Deficiency Blnk Deficiency Agammaglobulinemia Autosomal Recessive Due To Blnk Defect Agammaglobulinemia, Type 4, Autosomal Recessive
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07564	LCP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20761	Lcp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27275	Lcp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LCP2	VGNC	VGNC:42615
Felis catus	LCP2	VGNC	VGNC:68025
Bos taurus	LCP2	VGNC	VGNC:30818
Rattus norvegicus	LCP2	RGD	RGD:619743
Mus musculus	LCP2	MGD	MGI:1321402
Macaca mulatta	LCP2	VGNC	VGNC:74243
Others	LCP2	NCBI