NONO - non-POU domain containing octamer binding Gene

Also Known as P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4841

About NONO

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,283,635-71,301,168 (from NCBI)

This gene has 40 transcripts (splice variants), 217 orthologues, 7 paralogues and is associated with 62 phenotypes. Ubiquitous expression in ovary (RPKM 81.7), lymph node (RPKM 64.3) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

NONO Products (4)

mRNA	Protein	Name
NM_001145408.2	NP_001138880.1	non-POU domain-containing octamer-binding protein isoform 1
NM_001145409.2	NP_001138881.1	non-POU domain-containing octamer-binding protein isoform 1
NM_001145410.2	NP_001138882.1	non-POU domain-containing octamer-binding protein isoform 2
NM_007363.5	NP_031389.3	non-POU domain-containing octamer-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16148043	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15790595	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	28712728	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15790595	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nuclear matrix	IDA IDA: Inferred from direct assay	19874820	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15790595	GOA
is active in paraspeckles	IDA IDA: Inferred from direct assay	19716791	GOA
located in paraspeckles	IDA IDA: Inferred from direct assay	19217333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NONO Protein Structure

RRM_1

NOPS

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
non-POU domain-containing octamer-binding protein	54 kDa nuclear RNA- and DNA-binding protein

NONO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NONO	Q15233	C11orf68	Homo sapiens	Q9H3H3-3	Validated Y2H	32296183
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1-2	Anti Tag CoIP	28514442
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1-2	Validated Y2H	32296183
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Pull Down	16148043
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Anti Tag CoIP	33961781
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Y2H Array	25416956
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Anti Tag CoIP	16148043
Intra	NONO	Q15233	PSPC1	Homo sapiens	Q8WXF1	Y2H Pooling	16169070
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Y2H	21988832
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	35271311
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Crosslink	30021884
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	28514442
Intra	NONO	Q15233	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	33961781
Intra	NONO	Q15233	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	NONO	Q15233	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	NONO	Q15233	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	NONO	Q15233	PIN1	Homo sapiens	Q13526	Y2H Pooling	16189514
Intra	NONO	Q15233	C11orf68	Homo sapiens	Q9H3H3	Validated Y2H	25416956
Intra	NONO	Q15233	C11orf68	Homo sapiens	Q9H3H3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

NONO Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81661	NONO Antibody (YA1406)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81661A	NONO Antibody (YA1406)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked, Syndromic 34	MRXS34 Mental Retardation, X-Linked, Syndromic, Mircsof-Langouet Type Mrxsml Mental Retardation, X-Linked, Syndromic 34 Intellectual Developmental Disorder, X-Linked Syndromic 34 Mental Retardation, X-Linked, Syndromic, Type 34
Syndromic X-Linked Intellectual Disability 34	Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome Mental Retardation, X-Linked, Syndromic 34 Mrxs34 Mrxsml Syndromic X-Linked Mental Retardation Mircsof-Langouet Type
Renal Cell Carcinoma, Xp11-Associated	RCCX1 Mit Family Translocation Renal Cell Carcinoma Renal Cell Carcinoma, Papillary, 1 Carcinoma Associated With Mitf/Tfe Translocation Translocation Renal Cell Carcinoma Renal Cell Carcinoma Xp11-Associated Renal Cell Carcinoma Papillary 1 Carcinoma, Renal Cell, Xp11-Associated
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm
Alveolar Soft Part Sarcoma	ASPS Alveolar Soft-Part Sarcoma Sarcoma, Alveolar Soft Part Alveolar Soft Tissue Sarcoma Sarcoma Alveolar Soft Part Adult Alveolar Soft-Part Sarcoma Childhood Alveolar Soft-Part Sarcoma
Perivascular Epithelioid Cell Tumor	Pecoma Perivascular Epithelioid Cell Neoplasms Neoplasm With Perivascular Epithelioid Cell Differentiation
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-153918	(R)-SKBG-1	Inhibitor	99.68%	Unkown
HY-153918A	(S)-SKBG-1		99.01%	Unkown
HY-RS09425	NONO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18626	Nono Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25112	Nono Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991327	PAT-LM1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NONO	VGNC	VGNC:75367
Rattus norvegicus	NONO	RGD	RGD:1549738
Mus musculus	NONO	MGD	MGI:1855692
Bos taurus	NONO	VGNC	VGNC:32163
Canis familiaris	NONO	VGNC	VGNC:54178
Others	NONO	NCBI