PCOLCE - procollagen C-endopeptidase enhancer Gene

Also Known as PCPE; PCPE1; PCPE-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5118

About PCOLCE

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,602,363-100,608,175 (from NCBI)

This gene has 10 transcripts (splice variants), 246 orthologues and 35 paralogues. Ubiquitous expression in gall bladder (RPKM 64.6), endometrium (RPKM 44.2) and 21 other tissues.

Summary

Fibrillar Collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]

PCOLCE Products (1)

mRNA	Protein	Name
NM_002593.4	NP_002584.2	procollagen C-endopeptidase enhancer 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables collagen binding	IDA IDA: Inferred from direct assay	12393877	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	12393877	GOA
enables peptidase activator activity	IDA IDA: Inferred from direct assay	12393877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20207734	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCOLCE Protein Structure

CUB

NTR

0
100
200
300
400
449 a.a.

Protein Preferred Names	Protein Names
procollagen C-endopeptidase enhancer 1	procollagen C-proteinase enhancer 1 procollagen COOH-terminal proteinase enhancer 1 procollagen, type 1, COOH-terminal proteinase enhancer type 1 procollagen C-proteinase enhancer protein type I procollagen COOH-terminal proteinase enhancer

PCOLCE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Cross	PCOLCE	Q15113	Sdc2	Mus musculus	P43407	Solid Phase Assay	25286301
Cross	PCOLCE	Q15113	Sdc2	Mus musculus	P43407	Anti Bait CoIP	25286301
Intra	PCOLCE	Q15113	THBS1	Homo sapiens	P07996	SPR Array	24117177
Intra	PCOLCE	Q15113	P39060-PRO_0000005794	Homo sapiens	P39060-PRO_0000005794	Anti Bait CoIP	24117177
Intra	PCOLCE	Q15113	P39060-PRO_0000005794	Homo sapiens	P39060-PRO_0000005794	SPR Array	24117177
Intra	PCOLCE	Q15113	BMP1	Homo sapiens	P13497	SPR	20207734
Intra	PCOLCE	Q15113	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR Array	24117177
Cross	PCOLCE	Q15113	Sdc1	Mus musculus	P18828	Anti Bait CoIP	25286301
Cross	PCOLCE	Q15113	Sdc4	Mus musculus	O35988	Anti Bait CoIP	25286301
Cross	PCOLCE	Q15113	FN1	Bos taurus	P07589	Solid Phase Assay	25286301
Cross	PCOLCE	Q15113	FN1	Bos taurus	P07589	Anti Bait CoIP	25286301

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osteogenesis Imperfecta, Type Iii	Osteogenesis Imperfecta Type Iii OI3 Oi, Type Iii Osteogenesis Imperfecta Type 3 Oi Type 3 Oi Type Iii Progressive Deforming Osteogenesis Imperfecta Severe Osteogenesis Imperfecta Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae Progressively Deforming Osteogenesis Imperfecta With Normal Sclera Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae Progressively Deforming Oi Osteogenesis Imperfecta 3 Oi-Iii Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Alacrima, Achalasia, And Mental Retardation Syndrome	AAMR Alacrima, Achalasia, And Intellectual Disability Syndrome Alacrima, Achalasia, And Impaired Intellectual Development Syndrome Intellectual Disability
Stickler Syndrome, Type I	Stickler Syndrome 1 Stickler Syndrome Type 1 STL1 Aom Stickler Syndrome, Type 1 Stickler Syndrome, Vitreous Type 1 Stickler Syndrome, Membranous Vitreous Type Arthroophthalmopathy, Hereditary Progressive Arthro-Ophthalmopathy Hereditary Progressive Stickler Syndrome Membranous Vitreous Type Stickler Syndrome Type I Stickler Syndrome Vitreous Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS10163	PCOLCE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10164	Pcolce Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10165	Pcolce Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10166	PCOLCE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21248	Pcolce2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27765	Pcolce2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PCOLCE	VGNC	VGNC:44316
Rattus norvegicus	PCOLCE	RGD	RGD:3270
Felis catus	PCOLCE	VGNC	VGNC:68729
Macaca mulatta	PCOLCE	VGNC	VGNC:75782
Mus musculus	PCOLCE	MGD	MGI:105099
Bos taurus	PCOLCE	VGNC	VGNC:32642
Others	PCOLCE	NCBI