PRR16 - proline rich 16 Gene

Also Known as DSC54; LARGEN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51334

About PRR16

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:120,464,278-120,794,594 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 1.3), urinary bladder (RPKM 0.9) and 21 other tissues.

Summary

Involved in positive regulation of cell size and positive regulation of translation. [provided by Alliance of Genome Resources, Apr 2022]

PRR16 Products (4)

mRNA	Protein	Name
NM_001300783.2	NP_001287712.1	protein Largen isoform 1
NM_001308087.1	NP_001295016.1	protein Largen isoform 3
NM_001308088.1	NP_001295017.1	protein Largen isoform 3
NM_016644.2	NP_057728.1	protein Largen isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of cell size	IDA IDA: Inferred from direct assay	24656129	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	24656129	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR16 Protein Structure

DUF4589

0
100
200
304 a.a.

Protein Preferred Names	Protein Names
protein Largen	mesenchymal stem cell protein DSC54

PRR16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PRR16	Q569H4	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PRR16	Q569H4	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PRR16	Q569H4	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bestiality	Zoophilia
Penile Cancer	Penis Carcinoma Carcinoma Of Penis Penile Neoplasm Penile Carcinoma Penile Neoplasms Malignant Neoplasm Of Penis Ca Penis Malignant Neoplasm Of Body Of Penis Malignant Penile Tumor Penile Ca
Balanoposthitis	Balanitis Due To Infection
Methemoglobinemia And Ambiguous Genitalia	METAG Methemoglobinemia Type Iv Isolated 17,20-Lyase Deficiency, Pure Methemoglobinemia Due To Deficiency Of Cytochrome B5 Methemoglobinemia Type 4 Methemoglobinemia Type Iv, Formerly Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly Pure Isolated 17,20-Lyase Deficiency Methemoglobinemia, Type Iv
Phimosis	Tight Foreskin Tight Frenulum Congenital Phimosis
Cardiomyopathy, Dilated, 1a	Dilated Cardiomyopathy 1a Cdcd1 CMD1A Cardiomyopathy, Familial Idiopathic Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Idiopathic Dilated Cardiomyopathy, Congestive Dilated Cardiomyopathy With Conduction Defect 1 Cardiomyopathy Dilated With Conduction Defect Type 1 Cardiomyopathy, Dilated 1a Cardiomyopathy Dilated With Conduction Defect 1 Cardiomyopathy, Dilated, Type 1a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11226	PRR16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRR16	VGNC	VGNC:84482
Bos taurus	PRR16	VGNC	VGNC:106877
Mus musculus	PRR16	MGD	MGI:1918623
Felis catus	PRR16	VGNC	VGNC:102295
Rattus norvegicus	PRR16	RGD	RGD:1564528
Canis familiaris	PRR16	VGNC	VGNC:45041
Others	PRR16	NCBI