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C1orf56 - chromosome 1 open reading frame 56 Gene

Also Known as MENT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54964

About C1orf56

This gene has 3 transcripts (splice variants) and 87 orthologues. Broad expression in testis (RPKM 26.8), spleen (RPKM 8.3) and 24 other tissues.

Summary

This gene is a proto-oncogene whose promoter is methylated by DNA Methyltransferase 3B (DNMT3B), which represses the proto-oncogene. However, a catalytically inactive isoform of DNMT3B is overexpressed in lymphomas, leading to hypomethylation of the proto-oncogene's promoter and derepression of the proto-oncogene. [provided by RefSeq, Sep 2016]

C1orf56 Products (1)

mRNA	Protein	Name
NM_017860.5	NP_060330.2	protein MENT precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22133874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1orf56 Protein Structure

PMSI1

0
100
200
300
341 a.a.

Protein Preferred Names	Protein Names
protein MENT	methylated in normal thymocytes protein

C1orf56 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MENT	Q9BUN1	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	MENT	Q9BUN1	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	MENT	Q9BUN1	COX20	Homo sapiens	Q5RI15	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	COX20	Homo sapiens	Q5RI15	Y2H Array	32296183
Intra	MENT	Q9BUN1	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	MENT	Q9BUN1	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	MENT	Q9BUN1	CRX	Homo sapiens	O43186	Y2H Array	32296183
Intra	MENT	Q9BUN1	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Corneal Dystrophy, Posterior Polymorphous, 1	Posterior Polymorphous Corneal Dystrophy Ppcd Maumenee Corneal Dystrophy Posterior Polymorphous Corneal Dystrophy 1 PPCD1 Corneal Dystrophy, Hereditary Polymorphous Posterior Corneal Endothelial Dystrophy 1, Autosomal Dominant Schlichting Dystrophy Ched1 Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly Ched1, Formerly Hereditary Polymorphus Posterior Corneal Dystrophy Posterior Polymorphous Dystrophy Hereditary Polymorphous Posterior Corneal Dystrophy Dystrophy, Corneal, Posterior Polymorphous Dystrophy, Corneal, Posterior Polymorphous, Type 1 Polymorphous Corneal Dystrophy Corneal Endothelial Dystrophy 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01717	C1orf56 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1orf56	RGD	RGD:1359334
Mus musculus	C1orf56	MGD	MGI:2684974
Macaca mulatta	C1orf56	VGNC	VGNC:70392
Bos taurus	C1orf56	VGNC	VGNC:52715
Canis familiaris	C1orf56	VGNC	VGNC:49219
Others	C1orf56	NCBI