DNAJA4 - DnaJ heat shock protein family (Hsp40) member A4 Gene

Also Known as MST104; MSTP104; PRO1472

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55466

About DNAJA4

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Broad expression in heart (RPKM 43.9), testis (RPKM 33.4) and 23 other tissues.

Summary

Enables chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Apr 2022]

DNAJA4 Products (8)

mRNA Protein Name
NM_001130182.2 NP_001123654.1 dnaJ homolog subfamily A member 4 isoform 2
NM_001130183.2 NP_001123655.1 dnaJ homolog subfamily A member 4 isoform 3
NM_001387384.1 NP_001374313.1 dnaJ homolog subfamily A member 4 isoform 4
NM_001387385.1 NP_001374314.1 dnaJ homolog subfamily A member 4 isoform 2
NM_001387386.1 NP_001374315.1 dnaJ homolog subfamily A member 4 isoform 5
NM_001387387.1 NP_001374316.1 dnaJ homolog subfamily A member 4 isoform 6
NM_001387388.1 NP_001374317.1 dnaJ homolog subfamily A member 4 isoform 2
NM_018602.4 NP_061072.3 dnaJ homolog subfamily A member 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
21231916 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
21231916 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
23142051 GOA
involved in negative regulation of inclusion body assembly IDA
IDA: Inferred from direct assay
21231916 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23142051 GOA
involved in protein refolding IDA
IDA: Inferred from direct assay
21231916 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytosol IDA
IDA: Inferred from direct assay
21231916 GOA
located in membrane IDA
IDA: Inferred from direct assay
21231916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJA4 Protein Structure

DnaJ

DnaJ: DnaJ domain (7 - 65)

DnaJ_CXXCXGXG

DnaJ_CXXCXGXG: DnaJ central domain (135 - 201)

DnaJ_C

DnaJ_C: DnaJ C terminal domain (258 - 332)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily A member 4

  • DnaJ (Hsp40) homolog, subfamily A, member 4

DNAJA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DNAJA4 Q8WW22 DNAJA2 Homo sapiens O60884
Anti Tag CoIP
25036637
Intra
DNAJA4 Q8WW22 DNAJA2 Homo sapiens O60884
Lumier
25036637
Intra
DNAJA4 Q8WW22 ENDOG Homo sapiens Q14249
Anti Tag CoIP
25036637
Intra
DNAJA4 Q8WW22 ENDOG Homo sapiens Q14249
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

DNAJA4 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82957 DNAJA4 Antibody (YA2702) WB, IP Human, Rat
HY-P82957A DNAJA4 Antibody (YA2702)(PBS only) WB, IP Human, Rat

Related Diseases

Diseases Alias
Plantar Wart

  • Verruca Plantaris

  • Verrucae On Sole Of Foot

  • Mosaic Plantar Warts
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03860 DNAJA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DNAJA4 RGD RGD:1310035
Macaca mulatta DNAJA4 VGNC VGNC:84334
Bos taurus DNAJA4 VGNC VGNC:53935
Mus musculus DNAJA4 MGD MGI:1927638
Felis catus DNAJA4 VGNC VGNC:80985
Canis familiaris DNAJA4 VGNC VGNC:59071
Others DNAJA4 NCBI