SFMBT2 - Scm like with four mbt domains 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57713

About SFMBT2

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:7,158,624-7,411,490 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 4.8), ovary (RPKM 4.5) and 24 other tissues.

Summary

Enables histone binding activity. Involved in negative regulation of gene expression. Located in aggresome; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

SFMBT2 Products (5)

mRNA Protein Name
NM_001018039.1 NP_001018049.1 scm-like with four MBT domains protein 2 isoform 1
NM_001029880.3 NP_001025051.1 scm-like with four MBT domains protein 2 isoform 1
NM_001387889.1 NP_001374818.1 scm-like with four MBT domains protein 2 isoform 1
NM_001387890.1 NP_001374819.1 scm-like with four MBT domains protein 2 isoform 2
NM_001387891.1 NP_001374820.1 scm-like with four MBT domains protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables histone binding IDA
IDA: Inferred from direct assay
23385818 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23385818 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
23385818 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
23385818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFMBT2 Protein Structure

MBT

MBT: mbt repeat (78 - 150)

MBT

MBT: mbt repeat (193 - 258)

MBT

MBT: mbt repeat (304 - 379)

MBT

MBT: mbt repeat (412 - 483)

SLED

SLED: SLED domain (528 - 644)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (823 - 885)

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  • 800
  • 894 a.a.
Protein Preferred Names Protein Names

scm-like with four MBT domains protein 2

  • Scm-related gene containing four mbt domains 2

SFMBT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SFMBT2 Q5VUG0 SIAH1 Homo sapiens Q8IUQ4-2
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Prey Pooling
32296183
Intra
SFMBT2 Q5VUG0 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 L3MBTL3 Homo sapiens Q96JM7-2
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
SFMBT2 Q5VUG0 SCML1 Homo sapiens Q9UN30-2
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 SCML1 Homo sapiens Q9UN30-2
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 SCML1 Homo sapiens Q9UN30-2
Y2H Prey Pooling
32296183
Intra
SFMBT2 Q5VUG0 UBE2O Homo sapiens Q9C0C9
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 UBE2O Homo sapiens Q9C0C9
Y2H Prey Pooling
32296183
Intra
SFMBT2 Q5VUG0 UBE2O Homo sapiens Q9C0C9
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 SCML2 Homo sapiens Q9UQR0
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 SCML2 Homo sapiens Q9UQR0
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 SCML2 Homo sapiens Q9UQR0
Y2H Prey Pooling
32296183
Intra
SFMBT2 Q5VUG0 SLF2 Homo sapiens Q8IX21
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 SLF2 Homo sapiens Q8IX21
Y2H Prey Pooling
32296183
Intra
SFMBT2 Q5VUG0 SLF2 Homo sapiens Q8IX21
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 SCMH1 Homo sapiens Q96GD3
Validated Y2H
32296183
Intra
SFMBT2 Q5VUG0 PHC1 Homo sapiens P78364
Y2H Array
32296183
Intra
SFMBT2 Q5VUG0 PHC1 Homo sapiens P78364
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12768 SFMBT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SFMBT2 VGNC VGNC:65062
Macaca mulatta SFMBT2 VGNC VGNC:77280
Mus musculus SFMBT2 MGD MGI:2447794
Bos taurus SFMBT2 VGNC VGNC:34516
Canis familiaris SFMBT2 VGNC VGNC:46077
Rattus norvegicus SFMBT2 RGD RGD:1305027
Others SFMBT2 NCBI