SRR - serine racemase Gene

Also Known as ILV1; ISO1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63826

About SRR

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,303,378-2,325,264 (from NCBI)

This gene has 8 transcripts (splice variants), 121 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.5), testis (RPKM 6.3) and 25 other tissues.

Summary

Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and anion binding activity. Involved in pyruvate biosynthetic process; response to lipopolysaccharide; and serine family amino acid metabolic process. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SRR Products (2)

mRNA Protein Name
NM_001304803.1 NP_001291732.1 serine racemase isoform b
NM_021947.3 NP_068766.1 serine racemase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ATP binding IDA
IDA: Inferred from direct assay
20106978 GOA
enables L-serine ammonia-lyase activity IDA
IDA: Inferred from direct assay
18812225 GOA
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
16314870 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15681805 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
20106978 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20106978 GOA
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
20106978 GOA
enables serine racemase activity IDA
IDA: Inferred from direct assay
11054547 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in D-serine biosynthetic process IDA
IDA: Inferred from direct assay
11054547 GOA
involved in D-serine metabolic process IDA
IDA: Inferred from direct assay
20106978 GOA
involved in L-serine metabolic process IDA
IDA: Inferred from direct assay
11054547 GOA
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
18812225 GOA
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15681805 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16314870 GOA
located in neuronal cell body IDA
IDA: Inferred from direct assay
17880399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRR Protein Structure

PALP

PALP: Pyridoxal-phosphate dependent enzyme (21 - 314)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

serine racemase

  • D-serine ammonia-lyase

SRR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra
SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra
SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra
SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Y2H Prey Pooling
32296183
Intra
SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Validated Y2H
32296183
Intra
SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SRR Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83491 Serine Racemase Antibody (YA3236) WB, IP Human
HY-P83491A Serine Racemase Antibody (YA3236)(PBS only) WB, IP Human

Related Diseases

Diseases Alias
Immunodeficiency 24

  • Severe Combined Immunodeficiency Due To Ctps1 Deficiency

  • IMD24

  • Scid Due To Ctps1 Deficiency

  • Immunodeficiency, Type 24
Serine Deficiency
Glanders

  • Farcy Pipes

  • Infection Due To Pseudomonas Mallei

  • Burkholderia Mallei

  • Burkholderia Mallei Infection

  • Equina

  • Equine Glanders

  • Farcy

  • Farcy Buds

  • Farcy Cords

  • Infection Due To Actinobacillus Mallei

  • Infection Due To Malleomyces Mallei

  • Maliasmus

  • Malleus

  • Farce

  • Actinobacillosis

  • Actinobacillus Infection
Subacute Bacterial Endocarditis

  • Endocarditis Lenta

  • Sbe - Subacute Bacterial Endocarditis

  • Subacute Endocarditis, Lenta

  • Endocarditis, Subacute Bacterial
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Syndromic X-Linked Intellectual Disability Snyder Type

  • Snyder-Robinson Syndrome

  • Mental Retardation, X-Linked, Snyder-Robinson Type

  • Spermine Synthase Deficiency

  • Srs

  • Snyder-Robinson Mental Retardation Syndrome

  • X-Linked Intellectual Disability Snyder-Robinson Type

  • Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

  • Snyder-Robinson X-Linked Mental Retardation Syndrome
Psychotic Disorder

  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-W115558 L-Serine-O-sulfate potassium Inhibitor / Unkown
HY-RS13784 SRR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRR RGD RGD:735094
Felis catus SRR VGNC VGNC:65689
Bos taurus SRR VGNC VGNC:35292
Mus musculus SRR MGD MGI:1351636
Others SRR NCBI