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SH3BGRL3 - SH3 domain binding glutamate rich protein like 3 Gene

Also Known as TIP-B1; SH3BP-1; HEL-S-297

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83442

About SH3BGRL3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,280,086-26,281,522 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 3 paralogues. Ubiquitous expression in appendix (RPKM 140.1), colon (RPKM 114.4) and 25 other tissues.

Summary

Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

SH3BGRL3 Products (1)

mRNA	Protein	Name
NM_031286.4	NP_112576.1	SH3 domain-binding glutamic acid-rich-like protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
NOT enables glutathione transferase activity	IDA IDA: Inferred from direct assay	11137621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	34380438	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytosol	IDA IDA: Inferred from direct assay	11137621	GOA
located in ruffle membrane	IMP IMP: Inferred from mutant phenotype	34380438	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3BGRL3 Protein Structure

SH3BGR

0
93 a.a.

Protein Preferred Names	Protein Names
SH3 domain-binding glutamic acid-rich-like protein 3	SH3 domain binding glutamic acid-rich protein like 3

SH3BGRL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SH3BGRL3	Q9H299	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SH3BGRL3	Q9H299	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Prune Belly Syndrome	Eagle-Barrett Syndrome Abdominal Muscle Deficiency Syndrome PBS Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism Egbrs Eagle-Barret Syndrome Urethral Obstruction Sequence Obrinsky Syndrome Triad Syndrome Obrisnksy Syndrome Euos Early Urethral Obstruction Sequence Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism Abdomen Muscle Deficiency Syndrome Abdomen Muscular Deficiency Syndrome Abdominal Muscular Deficiency Syndrome Abdominal Muscle Aplasia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12829	SH3BGRL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SH3BGRL3	RGD	RGD:1308118
Mus musculus	SH3BGRL3	MGD	MGI:1920973
Felis catus	SH3BGRL3	VGNC	VGNC:65100
Bos taurus	SH3BGRL3	VGNC	VGNC:106924
Canis familiaris	SH3BGRL3	VGNC	VGNC:54866
Others	SH3BGRL3	NCBI