NUDT16L1 - nudix hydrolase 16 like 1 Gene

Also Known as SDOS; TIRR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84309

About NUDT16L1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,693,562-4,695,859 (from NCBI)

This gene has 5 transcripts (splice variants), 172 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 5.2), prostate (RPKM 4.4) and 25 other tissues.

Summary

Enables snoRNA binding activity. Involved in negative regulation of double-strand break repair via nonhomologous end joining. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NUDT16L1 Products (6)

mRNA Protein Name
NM_001193452.1 NP_001180381.1 tudor-interacting repair regulator protein isoform 2
NM_001370585.1 NP_001357514.1 tudor-interacting repair regulator protein isoform 3
NM_001370586.1 NP_001357515.1 tudor-interacting repair regulator protein isoform 4
NM_001370587.1 NP_001357516.1 tudor-interacting repair regulator protein isoform 5
NM_001370588.1 NP_001357517.1 tudor-interacting repair regulator protein isoform 6
NM_032349.4 NP_115725.1 tudor-interacting repair regulator protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
IDA: Inferred from direct assay
18820299 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
NOT enables protein homodimerization activity IDA
IDA: Inferred from direct assay
18820299 GOA
enables snoRNA binding IDA
IDA: Inferred from direct assay
18820299 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
28241136 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
28241136 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tudor-interacting repair regulator protein

  • NUDT16-like protein 1

NUDT16L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NUDT16L1 Q9BRJ7 METTL17 Homo sapiens Q9H7H0-2
Validated Y2H
32296183
Intra
NUDT16L1 Q9BRJ7 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
NUDT16L1 Q9BRJ7 CABP2 Homo sapiens Q9NPB3
Validated Y2H
32296183
Intra
NUDT16L1 Q9BRJ7 HNRNPH1 Homo sapiens P31943
Y2H Array
32296183
Intra
NUDT16L1 Q9BRJ7 HNRNPH1 Homo sapiens P31943
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
NUDT16L1 Q9BRJ7 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
NUDT16L1 Q9BRJ7 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
32296183
Intra
NUDT16L1 Q9BRJ7 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
NUDT16L1 Q9BRJ7 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
NUDT16L1 Q9BRJ7 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
NUDT16L1 Q9BRJ7 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
NUDT16L1 Q9BRJ7 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
NUDT16L1 Q9BRJ7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
NUDT16L1 Q9BRJ7 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Testicular Yolk Sac Tumor

  • Testicular Yolk Sac Neoplasm

  • Endodermal-Sinus Tumor

  • Orchidoblastoma

  • Yolk Sac Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09667 NUDT16L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NUDT16L1 VGNC VGNC:75474
Bos taurus NUDT16L1 VGNC VGNC:32331
Mus musculus NUDT16L1 MGD MGI:1914161
Canis familiaris NUDT16L1 VGNC VGNC:44029
Rattus norvegicus NUDT16L1 RGD RGD:1561451
Others NUDT16L1 NCBI