MACIR - macrophage immunometabolism regulator Gene

Also Known as C5orf30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90355

About MACIR

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:103,258,374-103,278,660 (from NCBI)

This gene has 3 transcripts (splice variants) and 168 orthologues. Broad expression in colon (RPKM 11.1), brain (RPKM 10.1) and 23 other tissues.

Summary

This gene, MACIR (previously known as C5orf30), has been associated with rheumatoid arthritis, functioning as a negative regulator of tissue damage and modulating the activity of synovial fibroblasts and macrophages. The encoded protein is highly conserved in vertebrate genomes but has no significant similarity to any Other human protein. [provided by RefSeq, Dec 2019]

MACIR Products (9)

mRNA Protein Name
NM_001316968.2 NP_001303897.1 macrophage immunometabolism regulator
NM_001316969.2 NP_001303898.1 macrophage immunometabolism regulator
NM_001377283.1 NP_001364212.1 macrophage immunometabolism regulator
NM_001377284.1 NP_001364213.1 macrophage immunometabolism regulator
NM_001377285.1 NP_001364214.1 macrophage immunometabolism regulator
NM_001377286.1 NP_001364215.1 macrophage immunometabolism regulator
NM_001377287.1 NP_001364216.1 macrophage immunometabolism regulator
NM_001377288.1 NP_001364217.1 macrophage immunometabolism regulator
NM_033211.4 NP_149988.1 macrophage immunometabolism regulator

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22085962 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
30659109 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in ciliary transition zone IDA
IDA: Inferred from direct assay
22085962 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22085962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MACIR Protein Structure

UNC119_bdg

UNC119_bdg: UNC119-binding protein C5orf30 homologue (3 - 200)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

macrophage immunometabolism regulator

  • UNC119-binding protein C5orf30

MACIR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
MACIR Q96GV9 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra
MACIR Q96GV9 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra
MACIR Q96GV9 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
25416956
Intra
MACIR Q96GV9 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
MACIR Q96GV9 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
MACIR Q96GV9 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
MACIR Q96GV9 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
MACIR Q96GV9 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
MACIR Q96GV9 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
MACIR Q96GV9 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
MACIR Q96GV9 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07943 MACIR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MACIR RGD RGD:1562136
Canis familiaris MACIR VGNC VGNC:52562
Macaca mulatta MACIR VGNC VGNC:70623
Bos taurus MACIR VGNC VGNC:52734
Mus musculus MACIR MGD MGI:1277184
Felis catus MACIR VGNC VGNC:60247
Others MACIR NCBI