DLGAP1 - DLG associated protein 1 Gene

Also Known as DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9229

About DLGAP1

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:3,496,032-4,455,307 (from NCBI)

This gene has 22 transcripts (splice variants), 286 orthologues and 4 paralogues. Biased expression in brain (RPKM 19.8), testis (RPKM 1.7) and 2 other tissues.

Summary

Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be part of postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP1 Products (29)

mRNA Protein Name
NM_001003809.3 NP_001003809.1 disks large-associated protein 1 isoform 2
NM_001242761.2 NP_001229690.1 disks large-associated protein 1 isoform 3
NM_001242762.2 NP_001229691.1 disks large-associated protein 1 isoform 4
NM_001242763.2 NP_001229692.1 disks large-associated protein 1 isoform 5
NM_001242764.2 NP_001229693.1 disks large-associated protein 1 isoform 6
NM_001242765.2 NP_001229694.1 disks large-associated protein 1 isoform 7
NM_001242766.2 NP_001229695.1 disks large-associated protein 1 isoform 8
NM_001308390.2 NP_001295319.1 disks large-associated protein 1 isoform 9
NM_001398525.1 NP_001385454.1 disks large-associated protein 1 isoform 10
NM_001398526.1 NP_001385455.1 disks large-associated protein 1 isoform 10
NM_001398527.1 NP_001385456.1 disks large-associated protein 1 isoform 1
NM_001398528.1 NP_001385457.1 disks large-associated protein 1 isoform 11
NM_001398530.1 NP_001385459.1 disks large-associated protein 1 isoform 12
NM_001398531.1 NP_001385460.1 disks large-associated protein 1 isoform 13
NM_001398532.1 NP_001385461.1 disks large-associated protein 1 isoform 14
NM_001398533.1 NP_001385462.1 disks large-associated protein 1 isoform 15
NM_001398534.1 NP_001385463.1 disks large-associated protein 1 isoform 16
NM_001398535.1 NP_001385464.1 disks large-associated protein 1 isoform 17
NM_001398536.1 NP_001385465.1 disks large-associated protein 1 isoform 18
NM_001398537.1 NP_001385466.1 disks large-associated protein 1 isoform 19
NM_001398539.1 NP_001385468.1 disks large-associated protein 1 isoform 20
NM_001398540.1 NP_001385469.1 disks large-associated protein 1 isoform 21
NM_001398541.1 NP_001385470.1 disks large-associated protein 1 isoform 22
NM_001398542.1 NP_001385471.1 disks large-associated protein 1 isoform 23
NM_001398543.1 NP_001385472.1 disks large-associated protein 1 isoform 24
NM_001398544.1 NP_001385473.1 disks large-associated protein 1 isoform 25
NM_001398545.1 NP_001385474.1 disks large-associated protein 1 isoform 26
NM_001398546.1 NP_001385475.1 disks large-associated protein 1 isoform 27
NM_004746.4 NP_004737.2 disks large-associated protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17474147 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLGAP1 Protein Structure

GKAP

GKAP: Guanylate-kinase-associated protein (GKAP) protein (640 - 977)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

disks large-associated protein 1

  • PSD-95/SAP90 binding protein 1

DLGAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DLGAP1 O14490 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
DLGAP1 O14490 DLG4 Homo sapiens P78352
Y2H Pooling
21653829
Intra
DLGAP1 O14490 DLG4 Homo sapiens P78352
FPS
22117215
Cross: Cross-species interaction Intra: Intraspecies interaction

DLGAP1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P85363 SAPAP1 Antibody (YA5055) IHC-P, ICC/IF, ELISA Human
HY-P85363A SAPAP1 Antibody (YA5055)(PBS only) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Retinitis Pigmentosa 55

  • RP55

  • Retinitis Pigmentosa, Type 55
Obsessive-Compulsive Disorder

  • OCD

  • Obsessive-Compulsive Disorder, Susceptibility To

  • Anancastic Neurosis

  • Obsessive Compulsive Disorder

  • Anankastic Neurosis

  • Obsessive-Compulsive Neurosis

  • Obsessive Compulsive Behavior
Trichotillomania

  • TTM

  • Hair-Pulling Syndrome

  • Compulsive Hair Plucking

  • Hair Pulling Disorder
Transient Tic Disorder
Childhood Acute Megakaryoblastic Leukemia

  • Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Phelan-Mcdermid Syndrome

  • Chromosome 22q13.3 Deletion Syndrome

  • 22q13.3 Deletion Syndrome

  • Telomeric 22q13 Monosomy Syndrome

  • PHMDS

  • Deletion 22q13 Syndrome

  • 22q13.3 Deletion

  • Deletion 22q13.3 Syndrome

  • Monosomy 22q13

  • Monosomy 22q13.3

  • 22q13 Deletion Syndrome

  • Monosomy 22q13 Syndrome

  • 22q13 Deletion

  • Chromosome Deletion
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Body Dysmorphic Disorder

  • Dysmorphophobia

  • Body Dysmorphia

  • Dysmorphic Syndrome

  • Body Dysmorphic Disorders
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Gilles De La Tourette Syndrome

  • Tourette Syndrome

  • Tourette Disorder

  • GTS

  • Ts

  • Gilles De La Tourette'S Syndrome

  • Motor-Verbal Tic Disorder

  • Guinon'S Disease

  • Psychogenic Tics

  • Tourette'S Syndrome

  • Chronic Motor And Vocal Tic Disorder

  • Td

  • Tourette'S Disease

  • Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

  • Combined Vocal And Multiple Motor Tic Disorder

  • Tic De La Tourette
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03801 DLGAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DLGAP1 MGD MGI:1346065
Canis familiaris DLGAP1 VGNC VGNC:39979
Rattus norvegicus DLGAP1 RGD RGD:620223
Bos taurus DLGAP1 VGNC VGNC:28088
Felis catus DLGAP1 VGNC VGNC:80437
Macaca mulatta DLGAP1 VGNC VGNC:97759
Others DLGAP1 NCBI