NUMBL - NUMB like endocytic adaptor protein Gene

Also Known as NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9253

About NUMBL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,665,905-40,690,651 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 8.6), endometrium (RPKM 7.2) and 25 other tissues.

Summary

Involved in cytokine-mediated signaling pathway and protein metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NUMBL Products (3)

mRNA Protein Name
NM_001289979.2 NP_001276908.1 numb-like protein isoform b
NM_001289980.2 NP_001276909.1 numb-like protein isoform b
NM_004756.5 NP_004747.1 numb-like protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
18299187 GOA
involved in protein metabolic process IDA
IDA: Inferred from direct assay
20079715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUMBL Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (80 - 201)

NumbF

NumbF: NUMB domain (287 - 372)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 609 a.a.
Protein Preferred Names Protein Names

numb-like protein

  • numb homolog-like

NUMBL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NUMBL Q9Y6R0 CDK5 Homo sapiens Q00535
Y2H Pooling
32814053
Intra
NUMBL Q9Y6R0 CDK5 Homo sapiens Q00535
Validated Y2H
32814053
Intra
NUMBL Q9Y6R0 CDK5 Homo sapiens Q00535
Y2H Array
32814053
Intra
NUMBL Q9Y6R0 CLSTN1 Homo sapiens O94985-2
Y2H Pooling
32814053
Intra
NUMBL Q9Y6R0 CLSTN1 Homo sapiens O94985-2
Validated Y2H
32814053
Intra
NUMBL Q9Y6R0 CLSTN1 Homo sapiens O94985-2
Y2H Array
32814053
Intra
NUMBL Q9Y6R0 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
NUMBL Q9Y6R0 RBFOX1 Homo sapiens Q9NWB1
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Differentiating Neuroblastoma
Neutropenia, Severe Congenital, X-Linked

  • X-Linked Severe Congenital Neutropenia

  • XLN

  • SCNX

  • Severe Congenital Neutropenia X-Linked

  • Neutropenia, Congenital, Severe, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09682 NUMBL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22696 Numbl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29210 Numbl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NUMBL VGNC VGNC:32349
Macaca mulatta NUMBL VGNC VGNC:75558
Rattus norvegicus NUMBL RGD RGD:1307579
Canis familiaris NUMBL VGNC VGNC:44043
Mus musculus NUMBL MGD MGI:894702
Felis catus NUMBL VGNC VGNC:68597
Others NUMBL NCBI