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Art. -Nr.: HY-170598

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HP211206

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HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity.
(Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3119106-17-8
Formel: C₄₂H₅₅F₂N₉O₁₀
Molecular Weight:883.94

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Data Sheet (266 KB)

HP211206 Chemical Structure

CAS. Nr.: 3119106-17-8

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Preis

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HP211206 is a SARS-CoV-2 main protease (M^pro) PROTAC degrader. HP211206 effectively degrades SARS-CoV-2 M^pro and its drug-resistant mutants. HP211206 has an IC₅₀ of 181.9 nM and a DC₅₀ of 621 nM for M^pro. HP211206 has antiviral activity^[1]. (Pink: SARS-CoV-2 Mpro ligand (HY-170599); Blue: Cereblon ligand (HY-41547); Black: linker (HY-B0236)).

IC₅₀ & Target

IC₅₀: 181.9 nM (SARS-CoV-2 M^pro);
DC₅₀: 621 nM (SARS-CoV-2 M^pro)^[1].

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 3119106-17-8
Appearance Solid
Molecular Weight 883.94
Formel C₄₂H₅₅F₂N₉O₁₀
Color Light yellow to green yellow
SMILES

O=C(CCC1N2C(C(C(NCCCCCC(N(C)[C@@H](C)C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N[C@H](C#N)C[C@H]4C(NCC4)=O)=O)C[C@@H](OC(F)F)C3)=O)=O)=O)=CC=C5)=C5C2=O)=O)NC1=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sang X, et al. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells. J Am Chem Soc. 2023 Dec 20;145(50):27248-27253. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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HP211206

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HP211206 Related Classifications

HY-170598 Related Classifications