INF200
Based on 1 publication(s) in Google Scholar
INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation.
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- CAS. Nr.: 3049730-43-7
- Formel: C13H13ClN2O4
- Molecular Weight:296.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
NLRP3[1]
Chemical Information
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CAS. Nr. 3049730-43-7
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Molecular Weight 296.71
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Formel C13H13ClN2O4
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SMILES
ClC1=CC=CC=C1CC(O2)=NN(CC(OCC)=O)C2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Sci
SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy. [Abstract]2024 Jan 1;20(2):585-605. PMID: 38169591
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
INF200 Related Classifications
HY-155517 Related Classifications
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